Makar, N., Elhawary, A., Emam, H., Abo Ria, N., Shaaban, E. (2020). Possible Beneficial Effect of Metformin Alone or in Combination with Methotrexate in Rheumatoid Arthritis Induced Rat Model. Benha Medical Journal, 37(1), 143-154. doi: 10.21608/bmfj.2020.89505
Nasr Makar; Abdel-Hamid Elhawary; Hanan Emam; Nashwa Abo Ria; Enas El-Sayed Shaaban. "Possible Beneficial Effect of Metformin Alone or in Combination with Methotrexate in Rheumatoid Arthritis Induced Rat Model". Benha Medical Journal, 37, 1, 2020, 143-154. doi: 10.21608/bmfj.2020.89505
Makar, N., Elhawary, A., Emam, H., Abo Ria, N., Shaaban, E. (2020). 'Possible Beneficial Effect of Metformin Alone or in Combination with Methotrexate in Rheumatoid Arthritis Induced Rat Model', Benha Medical Journal, 37(1), pp. 143-154. doi: 10.21608/bmfj.2020.89505
Makar, N., Elhawary, A., Emam, H., Abo Ria, N., Shaaban, E. Possible Beneficial Effect of Metformin Alone or in Combination with Methotrexate in Rheumatoid Arthritis Induced Rat Model. Benha Medical Journal, 2020; 37(1): 143-154. doi: 10.21608/bmfj.2020.89505
Possible Beneficial Effect of Metformin Alone or in Combination with Methotrexate in Rheumatoid Arthritis Induced Rat Model
1Department of clinical pharmacology, Benha faculty of medicine, Benha University, Egypt
2assistant lecturer of pharmacology, clinical pharmacology department, faculty of medicine, Benha university
Abstract
Background: Rheumatoid arthritis (RA) is a chronic, relapsing inflammatory and autoimmune multisystem illness that affects the joints. Methotrexate (MTX) is considered by many rheumatologists to be the most important and useful [DMARDs]. Metformin an antidiabetic medication has been reported to exert an anti-inflammatory effect. The rationale of this study is to test the effect of monotherapy with metformin alone or in comparison with methotrexate monotherapy on Adjuvant-induced arthritis (AIA). Aim of the study: The present study was designed to evaluate the effect of metformin alone and during basal treatment with methotrexate on rheumatoid factor, C-reactive protein, reduced glutathione, tumor necrosis factor- α, arthritis score and histopathological changes. Materials and methods: Rats were classified into: Group I: control normal group. Group II: was not treated (diseased group). Group III was treated with methotrexate (MTX). Group IV: was treated with metformin. Group V: was treated with combination of MTX with metformin. All treated groups received drugs for 4 weeks. Results: All groups showed significant improvement in all parameters and improvement of the histopathology of the joint. A significant reduction in the score was seen in all treated group at the end of 3rd and 4th weeks. Conclusion: All tested drugs alone or in combination showed improvement of parameters of RA. It is found that all combinations show more efficacy than each drug alone.
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