masoud, S., Bakr, M., Emara, N., Nasif, S. (2020). The Significance of Aldehyde Dehydrogenase 1A1 Expression in Benign Prostatic Hyperplasia, Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma. Benha Medical Journal, 37(1), 207-219. doi: 10.21608/bmfj.2020.82003
sara gamal masoud; Magda Bakr; Nashwa Emara; Sarah Nasif. "The Significance of Aldehyde Dehydrogenase 1A1 Expression in Benign Prostatic Hyperplasia, Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma". Benha Medical Journal, 37, 1, 2020, 207-219. doi: 10.21608/bmfj.2020.82003
masoud, S., Bakr, M., Emara, N., Nasif, S. (2020). 'The Significance of Aldehyde Dehydrogenase 1A1 Expression in Benign Prostatic Hyperplasia, Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma', Benha Medical Journal, 37(1), pp. 207-219. doi: 10.21608/bmfj.2020.82003
masoud, S., Bakr, M., Emara, N., Nasif, S. The Significance of Aldehyde Dehydrogenase 1A1 Expression in Benign Prostatic Hyperplasia, Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma. Benha Medical Journal, 2020; 37(1): 207-219. doi: 10.21608/bmfj.2020.82003
The Significance of Aldehyde Dehydrogenase 1A1 Expression in Benign Prostatic Hyperplasia, Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma
1pathology department, faculty of medicine, benha university, benha, elqaluobia, egypt
2Department of pathology, faculty of medicine, Benha university, Benha, Egypt
Abstract
Background: Prostatic carcinoma contains a small population of cancer stem cells (CSCs) that promote tumor growth, maintenance, and progression. CSC markers could provide a prognostic tool for human malignancies. Therefore, CSCs may have a role in prostatic carcinoma. This study aimed to evaluate the expression patterns and significance of stem cell marker aldehyde dehydrogenase 1A1 (ALDH1A1) in prostatic adenocarcinoma. Methods: This is a retrospective study performed upon 60 cases grouped as; 10 cases (16.7%) of benign prostatic hyperplasia (BPH), 6 cases (10%) of high-grade prostatic intraepithelial neoplasia (HGPIN) and 44 cases (73.3%) of prostatic adenocarcinoma (PCa) of different Gleason scores. Immunohistochemistry was applied on formalin-fixed, paraffin-embedded blocks using ALDH1A1. The relation between ALDH1A1 expression and clinicopathologic parameters was assessed. Results: Low expression of ALDH1A1 was seen in all cases (100%) of BPH, 5/6 (83.3%) of HGPIN and 12/44 (27.3%) of PCa, while high expression was in 1/6 case (16.7%) of HGPIN and 32/44 (72.2%) of PCa cases. There were significant relations between the expression levels of ALDH1A1 in PCa compared with HGPIN and BPH cases (P<0.01). ALDH1A1 expression showed highly significant associations with pre-operative serum PSA level, Gleason score, Gleason Grade Group (P<0.01) and was significantly associated with perineural invasion and tumor stage (P<0.05). No significant relations were found between ALDH1A1 expression and patients` age, capsular invasion, lymphovascular invasion, depth of invasion (pT) or lymph node metastasis. Conclusion: ALDH1A1 is a prostate CSC marker, could be involved in tumorigenesis and progression of prostatic adenocarcinoma
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