Letrozole & Misoprostol vs Misoprostol in Induction of 1st Trimesteric Abortion

Sadiq, Ahmed M.; Sweidan, Ibrahim I.; Mohammad, Wael N.; Soliman, Mayada S.

doi:10.21608/bmfj.2025.385026.2413

Letrozole & Misoprostol vs Misoprostol in Induction of 1st Trimesteric Abortion

Document Type : Original Article

Authors

¹ Professor of Obstetrics and Gynecology, Faculty of Medicine, Benha University

² Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Benha University

³ Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Benha University

⁴ M.B.B.Ch, Faculty of Medicine, Benha University

10.21608/bmfj.2025.385026.2413

Abstract

Background: A medical abortion in the first trimester is a safe and effective method to terminate a pregnancy, allowing women to make informed reproductive decisions. This study examined the safety and effectiveness of a combination of misoprostol and letrozole compared to misoprostol alone for medical abortions in the first trimester. Methods: Eighty women who visited the Obstetrics and Gynecology Department at Benha University Hospitals were part of a randomized trial. They were divided into two groups: Group I (Misoprostol) received a placebo for three days, followed by 800 µg of Misoprostol vaginally. Group II (Letrozole + Misoprostol) received 10 mg of Letrozole orally for three days, followed by 800 µg of Misoprostol vaginally. Results: Group I had a significant decrease in hemoglobin levels (0.65±0.14) compared to Group II (0.48±0.24), with a p-value of <0.001. Group II showed a higher success rate (p=0.044) and a shorter induction to abortion interval (p=0.006). Group I experienced more adverse effects (p=0.007). Conclusion: A combination of Letrozole and Misoprostol is a safer and more effective option than Misoprostol alone for first-trimester medical abortions.

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