Urinary Insulin-Like Growth Factor Protein 7 as An Early Indicator for Renal Affection in Multiple Myeloma

Document Type : Original Article

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Department of Internal Medicine, Faculty of Medicine, Benha University

Abstract

Background: Kidney injury in multiple myeloma (MM) is a prevalent complication and correlates with a poor prognosis. Early detection of kidney dysfunction is crucial for prompt management to control the illness and restore the function of the kidneys. Aim of the study: This work aimed to examine the role of urinary insulin-like growth factor binding protein 7 (IGFBP-7) as an early indicator for renal affection in MM. Methods: This prospective research has been performed on a total of 60 patients referred to Internal Medicine Department Benha University Hospitals. The participants have been separated into 2 groups: Group A: 40 cases with confirmed diagnosis of MM. Group B: 20 healthy participants with confirmed disease free of MM. Results: Urine IGFBP-7 is a significant indicator of renal affection in MM, with an AUC of 0.968 and a P value of below 0.0001. At a cutoff value of 9.89, it demonstrates excellent diagnostic performance, with a sensitivity of 93.3%, specificity of 97.8%, a positive predictive value (PPV) of 82.5%, and a negative predictive value (NPV) of 99.2%. Conclusions: In people with MM, urine IGFBP-7 may have utility of predicting renal affection in MM. Early detection of these indicators may enhance kidney results and prolong life expectancy in multiple myeloma.

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