Role of Splenic and Hepatic Stiffness Measurements in Determining the Degree of Thrombocytopenia in Patients with chronic Liver cirrhosis

Negm, Sherif; Abdelsameea, Eman; Khalif, Medhat; Gamal, Ghada

doi:10.21608/bmfj.2022.135478.1588

Role of Splenic and Hepatic Stiffness Measurements in Determining the Degree of Thrombocytopenia in Patients with chronic Liver cirrhosis

Document Type : Original Article

Authors

¹ Department of Internal Medicine and Hepatology, Faculty of Medicine, Benha University

² Department of hepatology and gastroenterology, National Liver Institute

³ Department of Internal Medicine and Hepatology, Faculty of Medicine, Benha University.

⁴ MBBCH

10.21608/bmfj.2022.135478.1588

Abstract

Background: The etiology of liver cirrhosis (LC) varies widely with many causes and fibrosis is the precursor of cirrhosis. Thrombocytopenia is common in advanced liver disease, as well as Splenomegaly. The degree of liver and spleen stiffness can be assessed noninvasively by liver stiffness measurements (LSM) called transient elastography (TE). Aim: to evaluate the relationship between spleen, liver stiffness measured by TE and the degree of thrombocytopenia in patients with LC. Methods: a cross-sectional study carried out on 50 patients suffering from compensated liver cirrhosis and has thrombocytopenia. Thrombocytopenia was categorized as mild (platelets count 75,000-150,000/µL), moderate (50,000-75,000/ µL) and severe (

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