Sadawi, M., Abo EL Azm, T., Tabl, M., Mohamed, M., Farag, S. (2025). Drug-coated balloon versus provisional percutaneous transluminal coronary angioplasty to side branch in bifurcation lesions. Benha Medical Journal, 42(2), 213-224. doi: 10.21608/bmfj.2024.302670.2119
Mohamed Sadawi; Tarek Helmy Abo EL Azm; Mohamed Abd EL Shafy Tabl; Mohamed Selim Mohamed; Sherien Ibrahim Farag. "Drug-coated balloon versus provisional percutaneous transluminal coronary angioplasty to side branch in bifurcation lesions". Benha Medical Journal, 42, 2, 2025, 213-224. doi: 10.21608/bmfj.2024.302670.2119
Sadawi, M., Abo EL Azm, T., Tabl, M., Mohamed, M., Farag, S. (2025). 'Drug-coated balloon versus provisional percutaneous transluminal coronary angioplasty to side branch in bifurcation lesions', Benha Medical Journal, 42(2), pp. 213-224. doi: 10.21608/bmfj.2024.302670.2119
Sadawi, M., Abo EL Azm, T., Tabl, M., Mohamed, M., Farag, S. Drug-coated balloon versus provisional percutaneous transluminal coronary angioplasty to side branch in bifurcation lesions. Benha Medical Journal, 2025; 42(2): 213-224. doi: 10.21608/bmfj.2024.302670.2119
Drug-coated balloon versus provisional percutaneous transluminal coronary angioplasty to side branch in bifurcation lesions
1Cardiology, Faculty of Medicine, Benha University, Egypt
2Professor of Cardiology, Faculty of Medicine, Benha University, Egypt
3Consultant of cardiology, National Heart Institute, Egypt
4Assistant Professor of Cardiology, Faculty of Medicine, Benha University, Egypt
Abstract
Background: Interventions involving coronary artery bifurcation lesions are technically demanding and have been historically linked with lower procedural success rates and poorer clinical outcomes compared to non-bifurcation lesions, necessitating specialized preparation and distinct expertise. This study aimed to contrast the application of drug-coated balloons with that of conventional balloons in the provisional stenting of coronary artery bifurcation lesions. Methods: The study is an interventional clinical trial . sixty participants who fulfilled the inclusion criteria were recruited into our study and divided into two categories: Group A: Patients who underwent provisional stenting using the traditional method with plain balloon angioplasty. Group B: Patients who underwent provisional stenting using a drug-coated balloon. Immediate patient outcomes were evaluated, and a clinical follow-up was conducted after six months to monitor for major adverse cardiac events. Results: Our study indicates that Drug-coated balloons (DCBs) have surfaced as a compelling therapeutic strategy in managing coronary bifurcation lesions. A substantial difference was noted between group A and group B to MACE after 6 months. The incidence of MACE was 28.6% (8 out of 30 patients) in group A, compared to 3.3% (1 patient) in group B, with a p-value of 0.02. However, no significant difference was observed between the two groups regarding in-hospital MACE in this study. The secondary endpoint of the study was defined as lesion success, and procedure success. Conclusion: our study highlighted the promising results of drug-coated balloons and their potential utilization in managing coronary artery bifurcation lesions.
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