Role of MicroRNA (182) in Differentiation Between Benign and Malignant Pleural Effusion

Document Type : Original Article

Authors

1 Chest Department, Faculty of Medicine, Benha University

2 Pofessor of Chest Diseases, Faculty of Medicine, Benha University

3 Assistant Professor of Clinical Pathology, Faculty of Medicine - Benha University

4 Assistant Professor of Chest Diseases, Faculty of Medicine, Benha University

5 M.B.B.Ch, Faculty of Medicine, Benha University

Abstract

Background: Differential diagnosis between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains a clinical challenge. Aim: to evaluate the role of microRNA (182) in differentiation between tuberculous (TPE) and malignant pleural effusion (MPE). Methods: This cross-sectional study included 60 patients admitted at the Chest Department, Benha University Hospital. Patients were divided into two groups based on pathology results: Group A (n=45): MPE and Group B: (n=15): TPE. miRNA 182 was measured by qt PCR in both groups and expressed as ΔΔCT and fold change(2-ΔΔCt ) Results: No statistically significant difference between MPE and TPE regarding ΔΔCT and fold change and the level did not differ significantly between malignant types. Adenosine deaminase (ADA) can significantly differentiate between malignant and TB groups (P

Keywords

Benha Medical Journal
Volume 42, Issue 4
April 2025
Pages 403-418

Files

Share

How to cite

Statistics