Mahdy, E., Abd El-Hamid, A., Ahmed Ibrahim Kotb, D., Rizk Ibrahim, E. (2025). Comparison between high flow nasal cannula and non-invasive mechanical ventilation in the management of patients with acute respiratory failure: A meta-analysis. Benha Medical Journal, 42(1), 23-35. doi: 10.21608/bmfj.2024.267052.2009
Enas Wageih Mahdy; Ahmed Mostafa Abd El-Hamid; Doaa Kamal Ahmed Ibrahim Kotb; Emad Fawzy Rizk Ibrahim. "Comparison between high flow nasal cannula and non-invasive mechanical ventilation in the management of patients with acute respiratory failure: A meta-analysis". Benha Medical Journal, 42, 1, 2025, 23-35. doi: 10.21608/bmfj.2024.267052.2009
Mahdy, E., Abd El-Hamid, A., Ahmed Ibrahim Kotb, D., Rizk Ibrahim, E. (2025). 'Comparison between high flow nasal cannula and non-invasive mechanical ventilation in the management of patients with acute respiratory failure: A meta-analysis', Benha Medical Journal, 42(1), pp. 23-35. doi: 10.21608/bmfj.2024.267052.2009
Mahdy, E., Abd El-Hamid, A., Ahmed Ibrahim Kotb, D., Rizk Ibrahim, E. Comparison between high flow nasal cannula and non-invasive mechanical ventilation in the management of patients with acute respiratory failure: A meta-analysis. Benha Medical Journal, 2025; 42(1): 23-35. doi: 10.21608/bmfj.2024.267052.2009
Comparison between high flow nasal cannula and non-invasive mechanical ventilation in the management of patients with acute respiratory failure: A meta-analysis
1Assistant Professor of Anesthesia & Intensive Care Faculty of Medicine - Benha University
2Department of anesthesia & intensive care, Faculty of Medicine, Benha University
3Department of Critical Care Medicine, Faculty of Medicine, Benha University
Abstract
Background: Acute respiratory failure is potentially life threatening. It does not require immediate intubation and the likelihood of a positive result hinges on the doctor's capacity to promptly identify the syndrome and implement suitable actions to aid and recover respiratory system function. Objectives: The research aimed to contrast the use of high-flow nasal cannula and non-invasive mechanical ventilation in treating patients experiencing acute respiratory failure. Study design: A meta-analysis study adhering to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines was conducted. Methods: Online databases (PubMed, Embase, Biomed, and the Cochrane Central Register of Controlled trials) were utilized to detect all published randomized studies that compare the impact of high-flow nasal cannula with non-invasive ventilation in patients dealing with acute respiratory failure. Results: Thirteen trials, encompassing a total of 1284 patients, were incorporated in the study. The risk of bias was minimal. The results revealed no substantial decrease in mortality. There was a significant reduction in length of hospital stay and a significant improvement in comfort score favouring the high flow nasal cannula group. However, there was no significant change in length of ICU stay, intubation rate, PaCO2, PaO2, PaO2/FiO2 ratio, SpO2, MAP and HR. Conclusion: This meta-analysis showed no significance of high flow nasal cannula over non-invasive mechanical ventilation in reducing mortality rates. However, high flow nasal cannula is associated with reduction of length of hospital stay and improvement of comfort score.
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