Improved Subclinical Left Ventricular dysfunction by global longitudinal strain in Dyslipidemic Patients After Statin Therapy

Document Type : Original Article

Authors

1 Cardiovascular Medicine Department, Faculty of Medicine – Mansoura University, Mansoura, Daqahlya, Egypt.

2 Cardiovascular Medicine Department, Faculty of Medicine, Suez University, Suez, Egypt

3 Cardiovascular Medicine Department, Faculty of Medicine – Mansoura University, Mansoura, Daqahlya, Egypt

4 Cardiovascular Medicine Department, Faculty of Medicine – Mansoura University, Mansoura, Daqahlya, Egypt.

5 Diagnostic and Interventional Radiology Department, Faculty of Medicine – Mansoura University, Mansoura, Daqahlya, Egypt

Abstract

Dyslipidemia is an important risk factor for cardiovascular diseases. Statin therapy is the principal treatment for dyslipidemia. Global longitudinal systolic strain (GLSS) is a reliable imaging technique used to identify subtle changes in the function of the left ventricle (LV), which often occur before significant impairment to LV function can be detected using the ejection fraction (EF). We aimed to assess subclinical structural myocardial abnormalities in dyslipidemic patients before and after statin therapy. The study compared global and segmental longitudinal systolic strain in thirty dyslipidemic patients with normal LVEF before and after 6 months of statin therapy and thirty healthy individuals. All participants underwent screening for lipid profile, conventional echocardiographic Doppler testing, and 2D speckle tracking. GLSS was impaired in dyslipedimic patients in comparison with control. This impairment was improved after 6 months of statin therapy. This suggests the presence of subclinical systolic dysfunction of the left ventricle, which improves with statins.

Keywords

Benha Medical Journal
Volume 42, Issue 1
January 2025
Pages 198-212

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