A study of association between miRNA-146a polymorphism and Acute Lymphoblastic Leukemia in children

Document Type : Original Article

Authors

1 Professor of Clinical and Chemical Pathology Faculty of Medicine -Benha University

2 lecturer of Clinical and Chemical Pathology Faculty of Medicine -Benha University

3 MBBCh Faculty of Medicine - Benha University

4 Assistant professor of Clinical and Chemical Pathology Faculty of Medicine -Benha University

Abstract

Background Acute lymphoblastic leukemia (ALL) is the most common type of pediatric hematopoietic leukemia in children, accounting for 30-35% of all pediatric cancers. Abnormal miRNA expression has been reported to be related to cancers and other diseases , miRNA 146a rs2910164 polymorphism has been widely examined in various types of cancers including hematological cancers . Methods: This case control study was conducted on 80 children with ALL (group I) who are admitted at Benha University Hospital and Benha Specialist Hospital for Children and 40 healthy children with matched age and sex as controls (group II) , we studied the miRNA-146a (rs2910164) polymorphism using Polymerase Chain Reaction-Restriction Fragment-Length Polymorphism (PCR-RFLP) approach. Results: Acute lymphoblasic leukemia (ALL) cases showed significantly higher proportions in GC, CC genotypes and C allele (40% for GG, 38.8% for GC, 21.2% for CC and 59.4% for G and 60.4% for C) (P= 0.023, 0.005, 1 for each). Conclusion: Our findings suggest that the miR-146a rs2910164 CC genotype was significantly associated with increased childhood ALL susceptibility .

Keywords

Benha Medical Journal
Volume 42, Issue 9
Special issue (clinical and chemical pathology)
September 2025
Pages 42-50

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