Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata

Document Type : Original Article

Authors

1 M.B.B.Ch, Faculty of Medicine, Al-Azhar University

2 Dermatology, Venereology and Andrology department, Faculty of Medicine – Benha University,Egypt

3 Dermatology, Venereology and Andrology department, Faculty of Medicine, Benha University,Egypt

4 Microbiology and Immunology department, Faculty of Medicine, Benha University

5 DERMATOLOGY ANDROLOGY DEPARTMENT FACULTY OF MEDICINE BENHA UNIVERSITY EGYPT

Abstract

Background: Alopecia areata (AA) is a persistent hair follicle inflammatory condition with T lymphocyte invasion. Interleukin-18 (IL-18) and inflammatory proteins such as NOD-like receptor family pyrin domain containing 3 (NLRP3) have been connected with several inflammatory and autoimmune skin conditions.
Objectives: To evaluate serum IL-18 and NLRP3 in patients with AA.
Materials and methods: This case-control study comprised 50 patients with AA and 50 normal, healthy persons of comparable age and sex as a control group. Severity of AA was evaluated using the SALT score. ELISA kits were used to determine serum IL-18 and NLRP3 levels.
Results: Serum IL-18 and NLRP3 levels were considerably greater in patients vs. controls (P= 0.01,

Keywords

Benha Medical Journal
Volume 42, Issue 1
January 2025
Pages 256-262

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