Circulating miR-30b-5p Level in Plasma as a Potential Biomarker for Early Detection of Breast Cancer

Document Type : Original Article

Authors

1 Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt

2 Lecturer of Clinical and Chemical Pathology, Faculty of Medicine, Benha University

3 Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

4 Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt

Abstract

Purpose: We aimed to assess the rule of plasma miR-30b- 5P as a biomarker for early diagnosis of breast cancer (BrC).
Patients and Methods: This case control study was conducted on 50 participants, females, newly diagnosed with breast cancer before receiving any treatment. Subjects were categorized into two groups: Group I (patient group): 35 adults, their age was (53.6 ± 12.20) years, are newly diagnosed BrC before any treatment and Group II (control group): 15 subjects, their age was (47.7 ± 9.59) years, apparently healthy matching age and sex with patients.
Results: There is statistically significant difference regarding presence of lesions by Mammogram when compare cases with control (p < .001). And there is a significant elevation in the expression of miR - 30 b - 5p when comparing cases with control group (p < .001).
Conclusion: Plasma miR-30b-5P can be used as a biomarker for early diagnosis of BrC.

Keywords

Benha Medical Journal
Volume 42, Issue 9
Special issue (clinical and chemical pathology)
September 2025
Pages 23-30

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