Sarcopenia and Bone Mineral Density In MAFLD Patients

Baiomy, Hossam Ameen; Alegaily, Hatem Samir; Elgazar, Ahmed Salah; Abdelaziz, Nermin Mohamed; Rezk, Samar M.; Hafez, Dalia Mohamed Ali

doi:10.21608/bmfj.2024.292480.2089

Sarcopenia and Bone Mineral Density In MAFLD Patients

Document Type : Original Article

Authors

¹ Professor Of Hepatology, Gastroenterology And Infectious Disease Faculty Of Medicine- Benha University

² Professor Of Hepatology , Gastroenterology And Infectious Disease Faculty Of Medicine- Benha University

³ Lecturer Of Hepatology, Gastroenterology And Infectious Disease Faculty Of Medicine- Benha University

⁴ Fellow Of Hepatology ,gastroenterology And Infectious Disease Mahalla Hepatology Teaching Hospital General Organization For Teaching Hospitals And Institutes

⁵ Fellow Of Nutrition Mahalla Hepatology Teaching Hospital General Organization For Teaching Hospitals And Institutes

⁶ MBBCh

10.21608/bmfj.2024.292480.2089

Abstract

Background : MAFLD affects about quarter of the world’s adult population, decreased bone mineral density and lean body mass share some common underlying mechanisms with MAFLD and it’s important to study the relation between these three conditions to design more effective management strategies for patients. AIM: This study aims to evaluate skeletal muscle mass and function together with bone mineral density in patients with MAFLD. Patients and Methods : This cross-sectional study was performed on 50 patients diagnosed with MAFLD, Bioelectrical Impedance Analysis (BIA) was done to assess appendicular skeletal muscle mass (ASM) and muscle strength was assessed by chair stand test (CS-30), bone mineral density (BMD) was assessed by Quantitative Ultrasound (QUS). Results : The mean age ±SD was 51.98± 10.96, there were 28 % male, 72 % female. There was statistically significant correlation between S3 steatosis and HBA1c & INR. Serum albumin was significantly lower in patients with F4 fibrosis. Sarcopenia was significantly associated with HBA1c and ALP . Risk of osteopenia and osteoporosis increase in MAFLD patients with advancing age. Receiver operating characteristic (ROC) analysis was performed to determine the value of BMD using QUS (T score) in prediction of sarcopenia. BMD at a cut off value 88.4 had 80% sensitivity& 60% specificity, with AUC was 0.636, and was non-significant (P = 0.143). Conclusion : MAFLD is associated with decreased skeletal muscle mass & function and BMD, so management strategies for patients with MAFLD should include screening and management for sarcopenia and low BMD.

Keywords