Naeem, W., K.Abbas, A., K.Elsayed, L., Goda Helal, A., Khatab, H., K.Naser, O., A. Bendary, A. (2024). Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid. Benha Medical Journal, 41(4), 197-205. doi: 10.21608/bmfj.2024.259420.1992
Wael Naeem; Ahmed K.Abbas; Labiba K.Elsayed; Ahmed Goda Helal; Heba Mohamed Khatab; Omar K.Naser; Ali A. Bendary. "Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid". Benha Medical Journal, 41, 4, 2024, 197-205. doi: 10.21608/bmfj.2024.259420.1992
Naeem, W., K.Abbas, A., K.Elsayed, L., Goda Helal, A., Khatab, H., K.Naser, O., A. Bendary, A. (2024). 'Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid', Benha Medical Journal, 41(4), pp. 197-205. doi: 10.21608/bmfj.2024.259420.1992
Naeem, W., K.Abbas, A., K.Elsayed, L., Goda Helal, A., Khatab, H., K.Naser, O., A. Bendary, A. Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid. Benha Medical Journal, 2024; 41(4): 197-205. doi: 10.21608/bmfj.2024.259420.1992
Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid
1Department of obstetrics and gynecology .benha university
2obstetrics & gynecology faculty of medicine Benha University
3benha
4Obstetrics&Gynecology Benha Faculty of medicine Benha University Egypt
5obstetrics & Gynecology department Ahmed Maher teaching Hospital Cairo ,Egypt
6obstetrics and gynecology department,Benha faculty of medicine,Benha university , Benha , Egypt
7Lecturer at department of Obstetrics & Gynecology, Faculty of Medicine, Benha University, Benha. Egypt.
Abstract
Back ground: Uterine leiomyoma represent over 75% of the amiable tumors in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue . The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising Endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway. Aim of this study : to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus .Patients and methods: This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination. Results : endometrial thickness was ˃10mm in 69.2% of premenopausal and ˃5mm in 83%of postmenopausal . endometrial hyperplasia is the commonest glandular endometrial change represent(37.5%) ,complex hyperplasia without atypia 5%,simple hyperplasia with atypia 5% and proliferative endometrium 22.5%of all review bunch . in premenopausal patients hyperplasia with atypia related with the most elevated E2 level ( 252,6 pg) , complex hyperplasia without atypia with E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ± 12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level (245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) .Conclusion : there is correlation between serum oestrogen level , histopathological changes of endometrium and symptomatic fibroid uterus at perimenopausal age .
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