Elnaggar, M., Mohamed, A., Osman, M., sweed, E., Elshahat, H., Mohammed, E. (2024). Serum Creatinine/Cystatin C Ratio in Chronic Obstructive Pulmonary Disease Patients and its Corelation to Disease Severity. Benha Medical Journal, 41(2), 205-219. doi: 10.21608/bmfj.2024.284759.2065
Marwa Elsayed Elnaggar; Ahmed Abdelsadek Mohamed; Maha Mamdouh Osman; enas mohammed sweed; Hagar Ismael Elshahat; Etemad Abdelsalam Mohammed. "Serum Creatinine/Cystatin C Ratio in Chronic Obstructive Pulmonary Disease Patients and its Corelation to Disease Severity". Benha Medical Journal, 41, 2, 2024, 205-219. doi: 10.21608/bmfj.2024.284759.2065
Elnaggar, M., Mohamed, A., Osman, M., sweed, E., Elshahat, H., Mohammed, E. (2024). 'Serum Creatinine/Cystatin C Ratio in Chronic Obstructive Pulmonary Disease Patients and its Corelation to Disease Severity', Benha Medical Journal, 41(2), pp. 205-219. doi: 10.21608/bmfj.2024.284759.2065
Elnaggar, M., Mohamed, A., Osman, M., sweed, E., Elshahat, H., Mohammed, E. Serum Creatinine/Cystatin C Ratio in Chronic Obstructive Pulmonary Disease Patients and its Corelation to Disease Severity. Benha Medical Journal, 2024; 41(2): 205-219. doi: 10.21608/bmfj.2024.284759.2065
Serum Creatinine/Cystatin C Ratio in Chronic Obstructive Pulmonary Disease Patients and its Corelation to Disease Severity
1Assistant professor of Chest Diseases, Faculty of Medicine, Benha University
2Professor of Chest Diseases, Faculty of Medicine, Benha University
3Lecturer of clinical and chemical pathology department, Faculty of medicine, Helwan University
4Assistant professor of radiology Department , Faculty of medicine– Banha University
5master degree in chest diseases and tuberculosis
6Lecturer of Chest Diseases, Faculty of Medicine, Benha University
Abstract
Background: Muscle atrophy is a major clinical feature of chronic obstructive pulmonary disease (COPD), and it is considered a strong predictor of mortality in COPD patients. This study aimed to assess the use of serum creatinine/serum Cystatin C ratio in the assessment of muscle wasting and disease severity in stable COPD patients. Methods: This case-control study included 70 COPD patients and 20 age and gender-matched healthy controls. Pulmonary function tests, measurement of the serum creatinine (Cr) and cystatin C (Cys-C) levels, chest high-resolution CT images (HRCT) for the assessment of low attenuation area percentage (LAA%) and Erector Spinae muscle (ESM) thickness, routine laboratory investigations and arterial blood gases (ABG). Results: There was a significant positive correlation between serum cystatin c and severity of COPD and LAA% but there was a significant negative correlation between serum cystatin c and Erector Spinae muscle cross-sectional area (ESMCSA), forced vital capacity %predicted (FVC% predicted), forced expiratory volume in 1 second (FEV1%predicted) FEV1/FVC%, and body mass index (BMI). Moreover, there was a significant positive correlation between creatinine/ cysC ratio and BMI, ESMCSA, FVC% predicted, FEV1/ FVC % and FEV1% predicted. The cut-off points of ESMCSA and Cr/Cys C for severe COPD were 23.4 cm2 and 0.87 respectively. Conclusion: The present study indicated that the Cr/Cys C ratio is an easy, inexpensive, repeatable, and promising tool that allows us to evaluate muscle wasting in COPD patients using serum markers as there is a positive correlation between the degree of muscle wasting and the severity of COPD.