Hemoglobin A1c levels and thrombus load in patients with type 2 diabetes mellitus and non-ST-segment elevation myocardial infarction

Document Type : Original Article

Authors

1 Assistant Professor of Cardiology Faculty of Medicine - Benha University

2 Department of Cardiology-Faculty of Medicine- Benha University

3 Department of Cardiology Faculty of Medicine - Benha University

4 Cardiology Department, Faculty of Medicine, Benha University

Abstract

Patients with Type 2 Diabetes Mellitus (T2DM) facing Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) often exhibit a higher incidence of thrombotic events. Hemoglobin A1c (HbA1c) levels, indicative of glycemic control, might influence the thrombus burden in such cases. This study aimed to evaluate the relationship between HbA1c, and coronary thrombus burden expressed as Thrombolysis in Myocardial Infarction (TIMI) thrombus grade, in NSTEMI patients. Methods: This cross-sectional comparative study was carried out on NSTEMI patients with T2DM who underwent early percutaneous coronary angiography. Patients were categorized into two groups based on HbA1c levels: Group I (optimal glycemic control, HbA1c ≤ 6.5%) and Group II (suboptimal glycemic control, HbA1c > 6.5%). Detailed clinical, laboratory, and angiographic assessments were performed. The primary outcome measure was the TIMI thrombus grade. Results: Group II showed significantly higher weight compared to Group I (P=0.026). Group II exhibited higher fasting blood glucose (FBG) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels (P

Keywords

Benha Medical Journal
Volume 41, Issue 1
(annual conference issue)
March and April 2024
Pages 199-210

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