ElBadawy, R., Alegaily, H., Abdelrahman Mohamed El Atrebi, K., Araby, E., Mohamed, A., Ezzat, M. (2024). Role of Intestinal Fatty Acid Binding Protein in Treated Inflammatory Bowel Diseases Patients. Benha Medical Journal, 41(2), 49-55. doi: 10.21608/bmfj.2024.242037.1920
Reda Mohamed ElBadawy; Hatem Samir Alegaily; Kamal El-Deen Abdelrahman Mohamed El Atrebi; Eman Mohamed Araby; Amal Ahmed Mohamed; Mohamed Samy Ezzat. "Role of Intestinal Fatty Acid Binding Protein in Treated Inflammatory Bowel Diseases Patients". Benha Medical Journal, 41, 2, 2024, 49-55. doi: 10.21608/bmfj.2024.242037.1920
ElBadawy, R., Alegaily, H., Abdelrahman Mohamed El Atrebi, K., Araby, E., Mohamed, A., Ezzat, M. (2024). 'Role of Intestinal Fatty Acid Binding Protein in Treated Inflammatory Bowel Diseases Patients', Benha Medical Journal, 41(2), pp. 49-55. doi: 10.21608/bmfj.2024.242037.1920
ElBadawy, R., Alegaily, H., Abdelrahman Mohamed El Atrebi, K., Araby, E., Mohamed, A., Ezzat, M. Role of Intestinal Fatty Acid Binding Protein in Treated Inflammatory Bowel Diseases Patients. Benha Medical Journal, 2024; 41(2): 49-55. doi: 10.21608/bmfj.2024.242037.1920
Role of Intestinal Fatty Acid Binding Protein in Treated Inflammatory Bowel Diseases Patients
1Department of Hepatology, Gastroenterology and Infectious diseases, Faculty of Medicine, Benha University.
2Department of internal medicine and gastroenterology, National Hepatology and Tropical Medicine Research Institute, Cairo.
3Department of Public health / family medicine Faculty of Medicine, Benha University.
4Department of Biochemistry, National Hepatology and Tropical Medicine Research Institute, Cairo.
Abstract
Background: Inflammatory bowel diseases (IBD) are a heterogeneous group of chronic relapsing diseases of the gastrointestinal tract. Intestinal fatty acid- binding proteins (I-FABP) defined as circulating or urinary markers of intestinal epithelial damage in patients with acute ischemia of the small bowel. Aim and objectives: to evaluate I-FABP level in the follow up of treated IBD patients compared to healthy control subjects. Subjects and methods: A case control study which included 60 patients was diagnosed IBD divided into equal two groups according to conventional or biological treatment and 30 healthy control subjects, aged from 16-70 years old. All investigations done accordingly plus I-FABP by Eliza. Results: In IBD females were 53% in conventional group. Laboratory findings were of statistical significant as regard higher Hb and lower number of platelets in biological group compared with conventional group, p value was .024 &.006 respectively. FABP levels were significantly elevated in studied IBD cases compared to control group, p value was .000 common complaint was abdominal pain in conventional group (70% versus 43.3% in biological group), while diarrhea was the most common in biological group (50% versus 20% in conventional group). Colonic left sided lesions in both groups. Cut off value of plasma FABP was 4.65 for all IBD patients with an AUC 98%, 77% and 0.992 respectively. Conclusion: I-FABP proved to be a useful biological marker in the diagnosis of IBD and can be used to monitor the progress of IBD.