Relationship between Helicobacter Pylori Morphological Forms in Gastric Biopsy and Helicobacter Pylori Stool Antigen

Metwally, Mohamed Abd El Aziz; Abd El Hamid, Hasnaa Shawky; Alegaily, Hatem Samir; Emara, Nashwa Mohamed; Aish, Abdelghany; Elsayed, Elsayed Abd El-Aziz; Abdelhamid, Mona Salah

doi:10.21608/bmfj.2024.249144.1951

Relationship between Helicobacter Pylori Morphological Forms in Gastric Biopsy and Helicobacter Pylori Stool Antigen

Document Type : Original Article

Authors

¹ Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine-Benha University

² Lecturer of Microbiology and Immunology Faculty of Medicine, Benha University

³ Professor of Hepatology, Gastroenterology and Infectious Diseases

⁴ Professor of pathology Faculty of Medicine-Benha University

⁵ Fellow of Gastroenterology, Hepatology and Infectious Diseases, Shebin El-Kom Teaching Hospital, Menoufia, Egypt

⁶ M.B, B.Ch. &ndash;TantaUniversity

⁷ Lecturer of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine-Benha University

10.21608/bmfj.2024.249144.1951

Abstract

Background: Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped microorganism and is responsible for colonization in the gastric microniche of more than 50% of the world population. This work aimed to compare H.pylori stool antigen titre in different H.pylori morphological forms in the gastric biopsy. Methodology: This study was carried out on 120 patients with dyspepsia. All patients were subjected to full history taking, upper GI endoscopy, and gastric biopsies according to Sydney protocol for histopathology and stool antigen test by using the H. pylori Antigen (ELISA) quantitative test kit. Results: Of the 120 patients there were 37 males and 83 females with a mean age of (29.57 ± 9.17), H.pylori morphological form was divided into two forms: Coccoid form (n = 27) and Bacillary form (n = 91). H. pylori gastritis was more common in females (69.17%) than males (30.83%), and common above the age of 30 years (56.7%), and more patients were nonsmokers (89.2%). H Pylori stool antigen was significantly higher in the case of the bacillary form of H. pylori than in the coccoid form. Conclusions: H. pylori stool antigen is higher in bacillary forms of H. pylori than in coccoid forms.

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