Significance of Dicer1 in Adrenocortical Adenoma and Carcinoma (Immunohistochemical Study)

Rashad, Heba Mohammed; Abdel Monem, Aya Abdel Aziz; Gouda, Mohebat Helmy; Abdelaziz, Taghreed Abdelsamee

doi:10.21608/bmfj.2023.228490.1875

Significance of Dicer1 in Adrenocortical Adenoma and Carcinoma (Immunohistochemical Study)

Document Type : Original Article

Authors

¹ Department of Pathology, Faculty of Medicine- Benha University, Banha University

² (M.B.B.CH)Pathology Faculty of Medicine, Banha University

³ Department of pathology , Benha faculty of medicine- Kafr shoker-Egypt

⁴ Department of pathology, faculty of medicine, benha university, benha, Egypt

10.21608/bmfj.2023.228490.1875

Abstract

BACKGROUND: Adrenocortical tumors (ACTs) are detected in 5–7% of the general population. Dysregulation of micro-ribonucleic acid (microRNA) biogenesis machinery is involved in a variety of human cancers. Dicer1 is an essential component of microRNA machinery. AIM: To evaluate the diagnostic and prognostic significance of Dicer1 in adrenocortical adenoma (ACA) and carcinoma (ACC) and correlate the results with clinico-pathological data. Material And Methods: Forty adrenocortical lesions were included in this retrospective study included (20) ACA and (20) ACC. Clinicopathological characteristics of examined cases were correlated with the IHC expression of Dicer1. RESULTS: Dicer1 IHC expression was more frequent in ACC (65%) than in ACA (25%), (p = .04). But among ACC, a weak Dicer1 expression was significantly more frequent in advanced ACCs. There was a significant statistical inverse relation between Dicer1 expression in studied ACC cases according to tumor size, weight, Weiss score, lymph node metastasis, lympho-vascular invasion and ENSAT stage (P < .05). Other clinico-pathological variables such as age, sex, tumor site, tumor grade, and distant metastasis showed no significant statistical difference (P >.05). Dicer1 showed 76% sensitivity and 67% specificity for malignant lesions.
CONCLUSION: Reduced Dicer1 expression with tumor progression in ACC may play a role in the tumorigenesis and further decline may be associated with poor prognosis in ACC.

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