ibrahiem, A., Abdel-aziz‎, A., Ghorab, D., yussif, S., Soliman, N. (2023). Inverse correlation of concurrent BCL2, and C MYC expressions and CD30 positivity as regard the Prognostic significance in diffuse large B-cell lymphoma. Benha Medical Journal, 40(Special issue (Academic)), 107-124. doi: 10.21608/bmfj.2023.213074.1829
afaf ibrahiem; Azza Abdel-aziz‎; Doaa Ghorab; shimaa yussif; Nahed Soliman. "Inverse correlation of concurrent BCL2, and C MYC expressions and CD30 positivity as regard the Prognostic significance in diffuse large B-cell lymphoma". Benha Medical Journal, 40, Special issue (Academic), 2023, 107-124. doi: 10.21608/bmfj.2023.213074.1829
ibrahiem, A., Abdel-aziz‎, A., Ghorab, D., yussif, S., Soliman, N. (2023). 'Inverse correlation of concurrent BCL2, and C MYC expressions and CD30 positivity as regard the Prognostic significance in diffuse large B-cell lymphoma', Benha Medical Journal, 40(Special issue (Academic)), pp. 107-124. doi: 10.21608/bmfj.2023.213074.1829
ibrahiem, A., Abdel-aziz‎, A., Ghorab, D., yussif, S., Soliman, N. Inverse correlation of concurrent BCL2, and C MYC expressions and CD30 positivity as regard the Prognostic significance in diffuse large B-cell lymphoma. Benha Medical Journal, 2023; 40(Special issue (Academic)): 107-124. doi: 10.21608/bmfj.2023.213074.1829
Inverse correlation of concurrent BCL2, and C MYC expressions and CD30 positivity as regard the Prognostic significance in diffuse large B-cell lymphoma
1pathology departement faculty of medicine mansoura university
2pathology departement, mansoura faculty of medicine
3pathology departement Mansoura faculty of Medicine
4pathology departement mansoura faculty of medicine
5Elrehab villa 43/8
Abstract
Background : C MYC, BCL2 and CD30 play an important role in initiation and propagation of diffuse large B-cell lymphoma (DLBCL). Protein expression of these marker were used in the diagnosis, predicting the prognosis and as a therapeutic target in DLBCL purpose: this study aimed to assess the prognostic impact and therapeutic utility of expression patterns of CD30, BCL2, MYC in DLBCL Patients and Methods: This retrospective study was carried out on DLBCL diagnosed at Oncology Centre Mansoura University (2016-2019). The study was approved by IRB of Mansoura faculty of Medicine Code Number: R.23.01.2043, 21/03/2023. Results: BCL2, C MYC, concurrent BCL2,C MYC and CD30 overexpression was present in 76%, 36%,, 26% and 26% of the studied cases respectively. Concurrent expressions of BCL2, C MYC showed significant association with the presence relapse (P= 0.003). concurrent expression of BCL2, C MYC revealed significant association with the progressive therapy response (P=0.003). In addition, C MYC, expression was significantly associated with the presence of exranodal presentation (P=0.03). CD30 protein overexpression was significantly associated with stage II and III (P=0.03). CD30 positivity showed inverse correlation with the concurrent expression of BCL2, C MYC (Correlation Coefficient=--.355, P=0,02). Also CD30 positivity and concurrent expression of BCL2, C MYC reflected significant prognostic impact on overall survival (OS) and disease free survival (DFS) (all P=0.00). Conclusion: concurrent C MYC, BCL2 overexpression is associated with a lower OS, and DFS. CD30 positivity is associated with a better OS, and DFS which can be utilized in management plan of DLBCL.
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