Role of Vitamin - D Deficiency in Term Neonates with late-onset sepsis at Benha University Hospitals

Shahin, Ashraf Mohammed; Fayed, Sahar Mohammed; El-Dien, Nehal Kamal; Mohamed, Nashwa Farouk

doi:10.21608/bmfj.2023.234610.1893

Role of Vitamin - D Deficiency in Term Neonates with late-onset sepsis at Benha University Hospitals

Articles in Press

Document Type : Original Article

Authors

¹ Professor of Pediatrics Faculty of Medicine – Benha University

² Professor of Clinical and Chemical Pathology Faculty of Medicine – Benha University

³ Department of Pediatrics Faculty of Medicine &ndash; Benha University

⁴ Lecturer of Pediatric Faculty of Medicine – Benha University

10.21608/bmfj.2023.234610.1893

Abstract

Background: Neonatal In both full-term and premature newborns, sepsis is the leading cause of death and illness.Aim: The purpose of this research was to determine whether or not there is a correlation between vitamin-D status and LOS in full-term infants. Methods: Eighty participants were randomly assigned to one of two groups: Group I (LOS group) consisted of 40 newborns diagnosed with LOS at presentation between 72 and 28 days of age. Forty full-term, healthy newborns made comprised Group II, the control group. All of the newborns involved in the study had a thorough history taken, a comprehensive clinical examination performed, and several laboratory tests performed, including a complete blood count, C- reactive protein, Random blood sugar, blood culture, urine culture, and CSF analysis and culture. The 25-hydroxyvitamin D (25-OH-D) levels were measured quantitatively using an auto chemiluminescence immunoassay instrument (Maccura i1000). The results showed that the LOS group had significantly lower vitamin D levels than the control group, as well as a significantly greater prevalence of vitamin D insufficiency and severe deficiency. Patients with a maternal history of diabetes, hypertension, or recurrent urinary tract infections also had lower vitamin D levels than their rural counterparts.Conclusion Vitamin D levels were positively correlated with the APGAR score, while total bilirubin levels were inversely correlated with Vitamin D levels. .

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