Bassyoni, O., Abdel Aal, E., khalil, A. (2023). Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study. Benha Medical Journal, 40(3), 745-758. doi: 10.21608/bmfj.2023.212530.1822
Omneya Youssef Bassyoni; Ebtehal Maher Abdel Aal; Ahmed khalil. "Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study". Benha Medical Journal, 40, 3, 2023, 745-758. doi: 10.21608/bmfj.2023.212530.1822
Bassyoni, O., Abdel Aal, E., khalil, A. (2023). 'Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study', Benha Medical Journal, 40(3), pp. 745-758. doi: 10.21608/bmfj.2023.212530.1822
Bassyoni, O., Abdel Aal, E., khalil, A. Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study. Benha Medical Journal, 2023; 40(3): 745-758. doi: 10.21608/bmfj.2023.212530.1822
Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study
3Department of gynacology and obstatric ,faculty of medicine ,Benha univeristy
Abstract
BACKGROUND : Ovarian cancer is a lethal gynecological malignancy worldwide. The immune system plays a key role in preventing tumor development. Angiogenesis and immune evasion are vital for ovarian cancer progression and metastasis. AIM: This work aimed to evaluate the expression of PD-L1, VEGF and CD8 +T cells in ovarian serous carcinomas and correlate them with clinicopathological variables. MATERIAL AND METHODS: An Immunohistochemical study was performed on 50 cases of ovarian serous carcinomas. RESULTS: PD-L1 & VEGF were over-expressed in higher grade, advanced stage , case with lymph node metastasis and distant metastasis .Higher CD8+ T cells in epithelium and stroma was related to advanced stage, only intraepithelial CD8+ T cells was directly correlated with tumor grade & lymph node metastasis positive correlation between PD-L1 & VEGF and Intraepithelial CD8+T cells was detected. CONCLUSION: Neoplastic cells expressing PD-L1 and VEGF along with intraepithelial CD8+T cells might expect poor prognosis. An association between PD-L1 and VEGF could predict their role in immune evasion. Administration of immunotherapy (anti PD-L1) with antiangiogenic agents might increase antitumor activity. To enhance our knowledge about the immunological environment of epithelial ovarian tumors requires larger-scale studies.