Significance of expression 	of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study

Bassyoni, Omneya Youssef; Abdel Aal, Ebtehal Maher; Khalil, Ahmed

doi:10.21608/bmfj.2023.212530.1822

Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study

Document Type : Original Article

Authors

¹ department of pathology ,faculty of medicine ,Benha univeristy

² Pathology department, Benha faculty of medicine, Benha university, Kafr Shokre, Egypt

³ Department of gynacology and obstatric ,faculty of medicine ,Benha univeristy

10.21608/bmfj.2023.212530.1822

Abstract

BACKGROUND : Ovarian cancer is a lethal gynecological malignancy worldwide. The immune system plays a key role in preventing tumor development. Angiogenesis and immune evasion are vital for ovarian cancer progression and metastasis.
AIM: This work aimed to evaluate the expression of PD-L1, VEGF and CD8 +T cells in ovarian serous carcinomas and correlate them with clinicopathological variables.
MATERIAL AND METHODS: An Immunohistochemical study was performed on 50 cases of ovarian serous carcinomas.
RESULTS: PD-L1 & VEGF were over-expressed in higher grade, advanced stage , case with lymph node metastasis and distant metastasis .Higher CD8+ T cells in epithelium and stroma was related to advanced stage, only intraepithelial CD8+ T cells was directly correlated with tumor grade & lymph node metastasis positive correlation between PD-L1 & VEGF and Intraepithelial CD8+T cells was detected.
CONCLUSION: Neoplastic cells expressing PD-L1 and VEGF along with intraepithelial CD8+T cells might expect poor prognosis. An association between PD-L1 and VEGF could predict their role in immune evasion. Administration of immunotherapy (anti PD-L1) with antiangiogenic agents might increase antitumor activity. To enhance our knowledge about the immunological environment of epithelial ovarian tumors requires larger-scale studies.

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