Estimated Glomerular Filtration Rate and Microalbuminuria as Biomarkers for Detection of Chronic Kidney Diseases in Obese and Overweight Egyptian Children

Omar, Hana Ramadan; Rashad, Mohamed Mahmoud; Abd Elgwad, Eman Ramadan; Abdelhamid, Mai Atef Abdelhamid Atef

doi:10.21608/bmfj.2023.208065.1808

Estimated Glomerular Filtration Rate and Microalbuminuria as Biomarkers for Detection of Chronic Kidney Diseases in Obese and Overweight Egyptian Children

Document Type : Original Article

Authors

¹ Department of Pediatrics, Faculty of Medicine- Benha University

² Department of Pediatrics , Faculty of Medicine- Benha University

³ Department of Clinical and chemical pathology, Faculty of Medicine-Benha

⁴ Depatement of Pediatrics department, Faculty of Medicine- Ain Shams University

10.21608/bmfj.2023.208065.1808

Abstract

World Health Organization (WHO) reports that kid obesity is a major problem for international health, particularly in low- and middle-income nations. Also, significant growth retardation in children is often caused by chronic renal illness (CKD); Objectives: This study aimed to evaluate the efficacy of estimated glomerular filtration rate and microalbuminuria in detecting chronic renal disease in overweight and obese Egyptian children. Patients and Methods: The participants in this cross-sectional research were 138 children aged 5 – 18 years. According to their BMI, there were 45 clinically healthy children as a control group, 43 overweight children and 50 obese children; Results: according to eGFR, there were 14 children (32.6%) with CKD in the overweight group and that there were 24 children (48%) with CKD in the obese group. Although the prevalence of CKD was higher in the obese group. According to microalbuminuria, there were 8 children (18.6%) with CKD in the overweight group while there were 15 children (30%) with CKD in the obese group. The prevalence of CKD was higher in the obese group, Conclusion: We find that the serum creatinine, serum urea, and albumin in urine levels are all significantly higher in the obese and overweight groups, whereas the eGFR is significantly lower. The eGFR increased with age and height in a statistically meaningful way. The eGFR was also inversely related to body mass index, creatinine, urea, white blood cell count, and creatinine in the urine. Moreover, there was a favourable connection between albumin/creatinine ratio and diastolic blood pressure

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