Bassyoni, O., Elshawarby, Z., Abostate, A. (2023). Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms. Benha Medical Journal, 40(2), 516-527. doi: 10.21608/bmfj.2023.223495.1854
Omneya Bassyoni; Zeinab Elshawarby; Ahmed Abostate. "Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms". Benha Medical Journal, 40, 2, 2023, 516-527. doi: 10.21608/bmfj.2023.223495.1854
Bassyoni, O., Elshawarby, Z., Abostate, A. (2023). 'Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms', Benha Medical Journal, 40(2), pp. 516-527. doi: 10.21608/bmfj.2023.223495.1854
Bassyoni, O., Elshawarby, Z., Abostate, A. Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms. Benha Medical Journal, 2023; 40(2): 516-527. doi: 10.21608/bmfj.2023.223495.1854
Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms
1department of pathology ,faculty of medicine ,Benha univeristy ,Benha ,Egypt
2Department of Pathology, faculty of medicine, benha university, benha, egypt
3department of general surgery , faculty of medicine ,Benha univeristy ,Egypt
Abstract
OBJECTIVE : Papillary breast neoplasms are heterogenous group of diseases consisting of wide range of benign, atypical and malignant lesions . Evaluation of such papillary neoplasms is considered one of the most problematic issues in diagnosis of breast pathology depending on H&E only as they need different treatment options. Aim: To differentiate papillary breast lesions depending on immunohistochemical staining of P63, SMA, CK14, chromogranin and ER. MATERIAL AND METHODS: An immunohistochemical profile using 5 markers were conducted on 75 papillary breast neoplasms. RESULTS: Out of 75 cases, 100% of duct papillomas were positive to P63& SMA. CK14 was positive in 90% of papilloma compared to malignant lesions : DCIS , intracystic papillary carcinomas , solid papillary carcinomas which were negative (84.0% , 92.3 % , 90.0% & 100.0% ,respectively ) .Solid papillary carcinomas were positive for chromgranin. .In 90% of DCIS , 92.3% intracystic papillary carcinomas , 90.0% solid papillary carcinomas and 100% of invasive micropapillary carcinomas- ER was homogenous positive compared to papillomas with heterogenous expression with statistical significant correlation (P