The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study)

Document Type : Original Article

Authors

1 pathology,faculty of medicie,Benha university,Egypt

2 urology department,benha faculty of medicine,benha university,benha, Egypt

3 pathology.faculty of medicine,Benha university,Benha

Abstract

Background : Prostate cancer is one of the most frequent malignancy worldwide . Mucin 4(MUC4) is a transmembrane mucin that is contributed in cell signalling events that guide the proliferation of cells. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been linked to tumorgenesis and progression of many cancers.
Aim: This study aimed to evaluate MUC4 and IMP-3 expression in different prostatic lesions and to relate the results with clinicopathological data.
Material & method:
This retrospective study examined 40 cases including10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasia (HGPIN) and 24 cases of prostatic adenocarcinoma (PCa) . MUC 4 and IMP-3 were used for the immunohistochemistry.
Results: MUC4 was detected in (100%) of BPH & HGPIN cases and (16.6%) of prostatic carcinoma.IMP3 expressed in (100%) of prostatic cancer cases and expressed in(10%) &(16.7%) of &HGPIN respectively. A significant statistical correlations between IMP3expression and stage, Gleason’s grade ,pre OP serum PSA level>10ng/ml, capsular and perineural invasion(P

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Benha Medical Journal
Volume 40, Issue 2
September and October 2023
Pages 462-473

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