prognostic Impact of Pretreatment Serum Lactate Dehydrogenase Levels in Adult Patients with Acute Myeloid Leukemia: Single Center Experience

Document Type : Original Article

Authors

1 Hematology unit, Internal Medicine Department, Faculty of Medicine, Mansoura Univerisity.

2 Hematology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University.

Abstract

Background: Lactate Dehydrogenase (LDH) elevation is considered a poor prognostic factor for numerous neoplastic diseases, including Acute Myeloid Leukemia (AML) which denotes leukemic cell turnover and cell destruction.
Patients and Methods: Fifty-two patients (27 males and 25 females) with newly diagnosed AML at the Hematology unit (Mansoura University) from October 2016 to November 2019 were recruited in this cohort study. They were categorized as favorable risk (7 [13.46%], intermediate risk (35 [67.3%], and adverse risk (10 [19.2%]). The LDH levels were measured initially at presentation for the patients and control group (n=15).
Results: The Mean LDH level was 1156 ± 744.49 U/L in the studied patients. The complete remission rate (CR) was statistically significantly higher in those with normal versus high LDH {[22 (71%) versus 9 (29%)], p value=0.003}. Cox proportional-hazards regression was used to analyze the effect of age, WBC, LDH, and adverse cytogenetics on Overall Survival (OS). Elevated LDH was found associated with shorter cumulative 3-year-OS in univariable (P value

Keywords

Benha Medical Journal
Volume 40, Issue 3
November and December 2023
Pages 684-692

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