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Metwally, R., Yousef Salem, M., Abdul fatah, A., Mohamady, R. (2023). The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats:Histological and Immunohistochemical study. Benha Medical Journal, 40(Annual conference issue), 49-64. doi: 10.21608/bmfj.2023.188421.1753
Randa Samy Metwally; Mohammed Mahmoud Yousef Salem; Al Shimaa Ezzat Abdul fatah; Rania E. El-Desoky Mohamady. "The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats:Histological and Immunohistochemical study". Benha Medical Journal, 40, Annual conference issue, 2023, 49-64. doi: 10.21608/bmfj.2023.188421.1753
Metwally, R., Yousef Salem, M., Abdul fatah, A., Mohamady, R. (2023). 'The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats:Histological and Immunohistochemical study', Benha Medical Journal, 40(Annual conference issue), pp. 49-64. doi: 10.21608/bmfj.2023.188421.1753
Metwally, R., Yousef Salem, M., Abdul fatah, A., Mohamady, R. The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats:Histological and Immunohistochemical study. Benha Medical Journal, 2023; 40(Annual conference issue): 49-64. doi: 10.21608/bmfj.2023.188421.1753

The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats:Histological and Immunohistochemical study

Article 4, Volume 40, Annual conference issue, March and April 2023, Page 49-64  XML PDF (1.73 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.188421.1753
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Authors
Randa Samy Metwally email 1; Mohammed Mahmoud Yousef Salem2; Al Shimaa Ezzat Abdul fatah3; Rania E. El-Desoky Mohamady4
1Depatement of Histology & cell Biology - Faculty of medicine - Benha University
2Departement of Histology & cell Biology - Faculty of medicine - Benha University
3Departemnt of Lecture of Histology & cell Biology - Faculty of medicine - Benha University
4Department of Histology and cell biology , ,faculty of medicine, benha university, Egypt
Abstract
Background: Doxorubicin (DOX) is highly effective anti-neoplastic agent, but it has side effects including cardiotoxicity. Moringa oleifera and vitamin E are potent antioxidants that prevent cardiotoxicity.
Objective: evaluate the possible protective role of moringa oleifera and vitamin E on doxorubicin-induced cardiotoxicity.

Materials and Methods: Sixty-five adult male albino rats were randomly divided into five groups. Group I (control group). Group II (affected group): rats were injected intraperitoneally with a cumulative dose of 15 mg/ kg of DOX for three weeks. Group III (moringa group): given in a dose of (500 mg/ kg/ day) by gastric tube orally for four weeks. Group IV (vitamin E group): given in a dose of (100 mg/ kg/ day) by gastric tube orally for four weeks. Group V (moringa and vitamin E). Heart specimens were taken and prepared for histological, immunohistochemical and EM examination.
Results: Group II showed disorganized, widely separated muscle fibers, cytoplasmic vacuolation, pyknosis of many cardiomyocyte nuclei, the mitochondria appeared distorted, extravasation of RBCs and inflammatory infiltrations. There was significant increase (P
Keywords
DOX; cardiotoxicity; moringa; vitamin E
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