The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats:Histological and Immunohistochemical study

Document Type : Original Article

Authors

1 Depatement of Histology & cell Biology - Faculty of medicine - Benha University

2 Departement of Histology & cell Biology - Faculty of medicine - Benha University

3 Departemnt of Lecture of Histology & cell Biology - Faculty of medicine - Benha University

4 Department of Histology and cell biology , ,faculty of medicine, benha university, Egypt

Abstract

Background: Doxorubicin (DOX) is highly effective anti-neoplastic agent, but it has side effects including cardiotoxicity. Moringa oleifera and vitamin E are potent antioxidants that prevent cardiotoxicity.
Objective: evaluate the possible protective role of moringa oleifera and vitamin E on doxorubicin-induced cardiotoxicity.

Materials and Methods: Sixty-five adult male albino rats were randomly divided into five groups. Group I (control group). Group II (affected group): rats were injected intraperitoneally with a cumulative dose of 15 mg/ kg of DOX for three weeks. Group III (moringa group): given in a dose of (500 mg/ kg/ day) by gastric tube orally for four weeks. Group IV (vitamin E group): given in a dose of (100 mg/ kg/ day) by gastric tube orally for four weeks. Group V (moringa and vitamin E). Heart specimens were taken and prepared for histological, immunohistochemical and EM examination.
Results: Group II showed disorganized, widely separated muscle fibers, cytoplasmic vacuolation, pyknosis of many cardiomyocyte nuclei, the mitochondria appeared distorted, extravasation of RBCs and inflammatory infiltrations. There was significant increase (P

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