Ahmed, E., Abdulhafeez, N., ABDELAZIZ, A., ABDELBAKY, S., EL-FALLAH, A. (2023). Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder. Benha Medical Journal, 40(1), 97-109. doi: 10.21608/bmfj.2022.177773.1721
Enas S. Ahmed; Neveen A. Abdulhafeez; AYA ABDELAZIZ; SHABIEB A ABDELBAKY; ASMAA A. EL-FALLAH. "Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder". Benha Medical Journal, 40, 1, 2023, 97-109. doi: 10.21608/bmfj.2022.177773.1721
Ahmed, E., Abdulhafeez, N., ABDELAZIZ, A., ABDELBAKY, S., EL-FALLAH, A. (2023). 'Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder', Benha Medical Journal, 40(1), pp. 97-109. doi: 10.21608/bmfj.2022.177773.1721
Ahmed, E., Abdulhafeez, N., ABDELAZIZ, A., ABDELBAKY, S., EL-FALLAH, A. Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder. Benha Medical Journal, 2023; 40(1): 97-109. doi: 10.21608/bmfj.2022.177773.1721
Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder
1Department of Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt
2Clinical Pathology Department-Faculty Of Medicine-Benha University
3Clinical & Chemical Pathology department, Faculty of Medicine, Benha University, Egypt
4Urology department, Faculty of Medicine, Benha University, Egypt
5assisat professor of Clinical and Chemical Pathology. Faculty of Medicine -Benha University
Abstract
Background: Bladder cancer is a very common malignancy worldwide its exact cause is not known, but it is believed to be multifactorial mostly caused by genetic mutations of tumor suppressor gene, proto-oncogenes and DNA repair genes including XRCC3 Thr241Met gene polymorphism. Aim of the study: Identify the link between XRCC3 (rs861539) gene polymorphism and the susceptibility to develop urothelial carcinoma of the bladder (UCB) in the Egyptian patients. Subjects and method: The presence of XRCC3 Thr241Met gene polymorphism (rs 861539) was identified by PCR-RFLP method in 50 patients with urothelial carcinoma of bladder and 50 healthy controls. Results: XRCC3 Thr 241 Met gene polymorphism CC genotype and C allele demonstrated a substantially increased susceptibility in the UCB group than the control group for the risk to develop UCB (OR 3.69, 95% CL 1.52-8.97) (P =0.003), however, while TT genotype and T allele demonstrated a substantially decreased susceptibility in the UCB group than the control group with a protective effect against UCB development (OR 0.096, 95%CL0.035-0.263) (P