Rashed, S., Abououf, E., Eraky, M., Barakat, A., Sadek, S., Ahmed, F., Mohammed, H. (2022). Effects of Ciprofloxacin loaded on silver nanoparticles on murine acute toxoplasmosis. Benha Medical Journal, 39(3), 941-953. doi: 10.21608/bmfj.2022.116115.1529
Samia Mohamed Mostafa Rashed; Eman Abdelrahman Abououf; Maysa Ahmad Eraky; Ashraf Mohammed Barakat; Sabry Atef Sadek; fayza Ali Ahmed; Hemat Salah Mohammed. "Effects of Ciprofloxacin loaded on silver nanoparticles on murine acute toxoplasmosis". Benha Medical Journal, 39, 3, 2022, 941-953. doi: 10.21608/bmfj.2022.116115.1529
Rashed, S., Abououf, E., Eraky, M., Barakat, A., Sadek, S., Ahmed, F., Mohammed, H. (2022). 'Effects of Ciprofloxacin loaded on silver nanoparticles on murine acute toxoplasmosis', Benha Medical Journal, 39(3), pp. 941-953. doi: 10.21608/bmfj.2022.116115.1529
Rashed, S., Abououf, E., Eraky, M., Barakat, A., Sadek, S., Ahmed, F., Mohammed, H. Effects of Ciprofloxacin loaded on silver nanoparticles on murine acute toxoplasmosis. Benha Medical Journal, 2022; 39(3): 941-953. doi: 10.21608/bmfj.2022.116115.1529
Effects of Ciprofloxacin loaded on silver nanoparticles on murine acute toxoplasmosis
1professor of medical Parasitology - Faculty of Medicine- Benha University
2Assistant Professor of Medical Parasitology Faculty of Medicine, Benha University
3professor of medical parasitology faculty of medicine benha university
4Professor of Epidemiology&Zoonotic diseases,National Research centre
5Research assistant in zoonotic disease department,National research centre
6medical parasitology.benha faculty of medicine,benha university
Abstract
Background: Toxoplasmosis is an infectious disease caused by Toxoplasma gondii. The Toxoplasma gondii strain has an impact on the severity of toxoplasmosis. The severity of infection is mostly determined by the host's immune response, with infections in immunocompetent people typically asymptomatic. Infection can induce neurological, ocular, and systemic disorders in immunocompromised patients. Nanomedicine developments appear promising, allowing toxoplasmosis to be treated with nanotechnology. Aim The aim of the present work was assessment the effect of ciprofloxacin and ciprofloxacin loaded on silver nanoparticles on murine acute toxoplasmosis. Materials and methods Mice were divided into 7 groups. Group I:Non Infected non-treated mice (5mice),Group II: Infected with acute strain (RH) non-treated mice (10 mice),Group III: Infected mice treated with Spiramycin 100mg/kg 10 mice),Group IV: Infected mice treated with ciprofloxacin 100mg/kg.(10 mice),Group V: Infected mice treated with ciprofloxacin loaded silver nanoparticles 100mg/kg.(10 mice),Group VI: Infected mice treated with silver nanoparticles(10 mice).GroupVII:non infected treated with silver nanoparticles(5mice). Effect of treatment was assessed by counting the number of tachyzoites in peritoneal fluid,survival rate and histopathological assessment of liver. Results Ciprofloxacin treated group showed significant reduction in tachyzoite count in peritoneal fluid, induced morphological alteration in shape of tachyzoites and improved histopathological picture in liver tissue but didn’t significantly improve survival rate in infected mice. The effect of Ciprofloxacin was augmented after loading it on silver nanoparticles. Conclusion Ciprofloxacin proved its effectiveness against experimental acute toxoplasmosis and its effect was augmented after loading it on silver nanoparticles.
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