Study of The Role of Soluble Mannose Receptor (sMR/sCD206) in Multiple Myeloma

Document Type : Original Article

Authors

1 clinical & chemical pathology dep., Faculty of Medicine, Benha university , Egypt

2 Clinical and chemical pathology department, Benha Faculty of Medicine, Benha university, Benha, Egypt

3 Clinical Oncology and Nuclear Medicine Faculty of Medicine -Menoufia University

4 Clinical pathology, Faculty of medicine,Benha University

5 Clinical and chemical pathology Faculty of Medicine, Benha University

Abstract

Background: Multiple Myeloma is an incurable B cell tumor characterized by the accumulation of malignant plasma cells in the bone marrow (BM). Objective: to assess serum level of soluble mannose receptor (sMR/CD206) in multiple myeloma patients and to predict its role in pathogenesis of multiple myeloma. Methods: A case- control study was conducted on thirty Egyptian patients (15 males and 15 females; their age ranged between 40-73 years) diagnosed with multiple myeloma and twenty race and sex matched healthy controls. Patients attending the clinical oncology and nuclear medicine department ,Faculty of medicine , Menofia University. Informed consent was obtained from the patients and this study was approved by local ethical committee of Faculty of medicine, Menofia University and Benha University Hospital. Results: All studied MM cases were evaluated, 26.6% had ISS I, 40% had ISS II and 33.3% had ISS III. Hemoglobin level was significantly lower in MM cases when compared to control group (P0.05 for each). MM patients had significantly higher sMR level when compared to control group at diagnosis (P value

Keywords

Benha Medical Journal
Volume 39, Issue 3
November and December 2022
Pages 850-857

Files

Share

How to cite

Statistics