Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates

Aly, Iman; Abdelrahman, Amira; Montaser, Omnia Gamal; Abed, Neveen

doi:10.21608/bmfj.2022.140246.1597

Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates

Document Type : Original Article

Authors

¹ Pediatric department, Faculty of Medicine – Benha University

² Clinical & Chemical Pathology, Faculty of Medicine – Banha University,

³ pediatric department Benha faculty of medicin Benha university

10.21608/bmfj.2022.140246.1597

Abstract

Background: Data on Protein Z (PZ) level may be useful in neonatal respiratory distress syndrome (RDS) as in RDS the defect in both coagulation and fibrinolytic system may play a role in the pathogenesis and progression of the disease.
Aim: To evaluate plasma protein Z levels in neonatal respiratory distress syndrome.
Methods: This study was performed on 40`neonates diagnosed with respiratory distress syndrome and 40 age and sex matched apparently healthy neonates as controls. Plasma Protein Z levels were assessed in plasma of all neonates by ELISA.
Results: There was statistically significant decrease in Plasma Protein Z level among patients than controls. In addition, a significant decrease in PZ was present with increasing the severity of the disease. There was a significant decrease in PZ among died than survived patients. A significant positive correlation was observed between PZ level and gestational age while a significant negative correlation was observed between PZ and (severity, down score).
Conclusion: Plasma Protein Z. level is decreased in neonatal respiratory distress syndrome and it may be a good biomarker for detection of the severity and prognosis of the disease.

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