Aly, I., Abdelrahman, A., Montaser, O., Abed, N. (2022). Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates. Benha Medical Journal, 39(3), 805-816. doi: 10.21608/bmfj.2022.140246.1597
Iman Aly; Amira Abdelrahman; Omnia Gamal Montaser; Neveen Abed. "Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates". Benha Medical Journal, 39, 3, 2022, 805-816. doi: 10.21608/bmfj.2022.140246.1597
Aly, I., Abdelrahman, A., Montaser, O., Abed, N. (2022). 'Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates', Benha Medical Journal, 39(3), pp. 805-816. doi: 10.21608/bmfj.2022.140246.1597
Aly, I., Abdelrahman, A., Montaser, O., Abed, N. Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates. Benha Medical Journal, 2022; 39(3): 805-816. doi: 10.21608/bmfj.2022.140246.1597
Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates
1Pediatric department, Faculty of Medicine – Benha University
2Clinical & Chemical Pathology, Faculty of Medicine – Banha University,
3pediatric department
Benha faculty of medicin
Benha university
Abstract
Background: Data on Protein Z (PZ) level may be useful in neonatal respiratory distress syndrome (RDS) as in RDS the defect in both coagulation and fibrinolytic system may play a role in the pathogenesis and progression of the disease. Aim: To evaluate plasma protein Z levels in neonatal respiratory distress syndrome. Methods: This study was performed on 40`neonates diagnosed with respiratory distress syndrome and 40 age and sex matched apparently healthy neonates as controls. Plasma Protein Z levels were assessed in plasma of all neonates by ELISA. Results: There was statistically significant decrease in Plasma Protein Z level among patients than controls. In addition, a significant decrease in PZ was present with increasing the severity of the disease. There was a significant decrease in PZ among died than survived patients. A significant positive correlation was observed between PZ level and gestational age while a significant negative correlation was observed between PZ and (severity, down score). Conclusion: Plasma Protein Z. level is decreased in neonatal respiratory distress syndrome and it may be a good biomarker for detection of the severity and prognosis of the disease.
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