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Badr, N., Rashad, M., Ismail, Y., Sobeih, A. (2022). Study Of Some Blood Biomarkers During Bronchial Asthma Flare-ups. Benha Medical Journal, 39(3), 788-804. doi: 10.21608/bmfj.2022.135291.1587
Nouran Ramzy Badr; Mohamed Mahmoud Rashad; Yasser Mahmoud Ismail; Ahmed Ata Sobeih. "Study Of Some Blood Biomarkers During Bronchial Asthma Flare-ups". Benha Medical Journal, 39, 3, 2022, 788-804. doi: 10.21608/bmfj.2022.135291.1587
Badr, N., Rashad, M., Ismail, Y., Sobeih, A. (2022). 'Study Of Some Blood Biomarkers During Bronchial Asthma Flare-ups', Benha Medical Journal, 39(3), pp. 788-804. doi: 10.21608/bmfj.2022.135291.1587
Badr, N., Rashad, M., Ismail, Y., Sobeih, A. Study Of Some Blood Biomarkers During Bronchial Asthma Flare-ups. Benha Medical Journal, 2022; 39(3): 788-804. doi: 10.21608/bmfj.2022.135291.1587

Study Of Some Blood Biomarkers During Bronchial Asthma Flare-ups

Article 3, Volume 39, Issue 3, November and December 2022, Page 788-804  XML PDF (922.78 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.135291.1587
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Authors
Nouran Ramzy Badr email 1; Mohamed Mahmoud Rashad2; Yasser Mahmoud Ismail3; Ahmed Ata Sobeih4
1Pediatric department, Faculty of medicine, Benha University, Benha, Egypt
2Paediatric Medicine Department, Faculty of Medicine-Benha University
3Clinical pathology department - Faculty of Medicine - Benha Univeristy
4Pediatric , Faculty of medicine , Benha University
Abstract
Background: Bronchial asthma is one of the most common chronic pediatric diseases. It is a heterogeneous disease with multiple overlapping phenotypes. Biomarkers have been investigated for better phenotype characterization and to identify the response to targeted therapies. Purpose: The study aimed to assess serum periostin level and mean platelet volume in children with asthma flare-ups compared to age and sex-matched healthy controls. Methods: This case-control study included one hundred asthmatic children and fifty healthy children as controls. Both groups were aged 6-12 years. Bronchial asthma was diagnosed according to the Global Initiative for Asthma (1). Blood mean platelet volume and serum periostin levels were assessed for both groups. Results: The mean platelet volume was significantly lower in the patients group (9±1 fL) than in the controls (11±1 fL) (P < 0.001). Serum periostin was significantly higher in the patients group (78.85±26.33 ng/ml) than in the controls (42.72±3.4 ng/ml) (P
Keywords
Keywords: Asthma; Biomarker; Flare-ups; Periostin
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