ElKady, M., Elkholy, H., Ismail, Y., El Sayed, A. (2022). Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma. Benha Medical Journal, 39(2), 515-528. doi: 10.21608/bmfj.2022.118011.1534
Mostafa ElKady; Hany Elkholy; Yasser Ismail; Ahmed Mohamed El Sayed. "Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma". Benha Medical Journal, 39, 2, 2022, 515-528. doi: 10.21608/bmfj.2022.118011.1534
ElKady, M., Elkholy, H., Ismail, Y., El Sayed, A. (2022). 'Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma', Benha Medical Journal, 39(2), pp. 515-528. doi: 10.21608/bmfj.2022.118011.1534
ElKady, M., Elkholy, H., Ismail, Y., El Sayed, A. Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma. Benha Medical Journal, 2022; 39(2): 515-528. doi: 10.21608/bmfj.2022.118011.1534
Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma
1Hepatology, Gastroenterology and Infectious Disease Department, Faculty of Medicine, Banha Universty
2Clinical and Chemical Pathology Department, Faculty of Medicine, Banha Universty
3M.B.B.CH, Ministry of Health, Kafr Shokr Central Hospital
Abstract
Background: Hepatocellular carcinoma (HCC) is a global health problem. It is the second most common cause of cancer-related mortality and the sixth most common cause of cancer worldwide, HCC development risk factors include chronic viral hepatitis, alcoholic and non-alcoholic fatty liver disorders and other forms of chronic hepatitis inflammatory illnesses ,The aim: to study the clinical usefulness of serum Neuropilin 1(NRP 1) as a diagnostic marker for HCC. Methods: This cross-sectional study was conducted on 90 individuals divided into three groups: Group I: Thirty patients with HCC, Group II: Thirty patients with liver cirrhosis(LC), Group III: Thirty apparently healthy subjects. All patients were subjected to full medical history taking, thorough clinical examination and determination of the serum level of NRP 1. Results; NRP1 level was significantly higher in HCC when compared to LC group. Also, NRP 1 level was significantly higher in HCC and LC groups when compared to control group. ROC curve of serum NRP1 showed sensitivity was 93.3%, specificity 80%, PPV of 82.4% and NPV of 92.3% with AUC of 0.842 at cutoff value of 4030 pg/ml. Conclusion: NRP-1 may represent a potential diagnostic marker for HCC
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