Protective effect of spirulina fusiform in chronic colitis in male albino rats

Ettesh, Reham; Alnoury, Heba; Ismail, Yasmeen; Yacoub, Mary

doi:10.21608/bmfj.2022.18446.1111

Protective effect of spirulina fusiform in chronic colitis in male albino rats

Document Type : Original Article

Authors

¹ pharmacology, faculty of medicine ,kafr-elshekh university, fuwa,egypt

² pharmacology,faculty of medicine ,benha,benha

³ Clinical Pharmacology,Faculty of medicine, Benha university,Benha ,Benha .

10.21608/bmfj.2022.18446.1111

Abstract

Background/Objectives: In this work, a modified low dose model of induction of ulcerative colitis was used including the administration of single intra-rectal instillation of 1 ml of 5% acetic acid followed by 2% dextran sodium sulfate for 7 days. Moreover, aqueous suspension of Spirulina (500 mg /kg stomach gavage)was prophylactically used 7 days before disease induction . Antioxidant, anti-inflammatory effect was achieved by spirulina
.
Aim: The aim of this study was to determine the effectiveness of spirulina as a new, safe in treatment of ulcerative colitis
Material and methods: Chronic UC was induced by 1ml 5% intracolonic acetic acid instillation in adult male albino rats as single dose following by adding 2% DSS orally in drinking water for 7 days. Intragastric administration of spirulina. (500 mg/kg/day) was administrated 7 days before acetic acid instillation and continued for the end of the experiment.
Disease activity index (DAI), colonic oxidative stress markers, tumor necrosis factor (TNF)-a levels, IL1B, and the colonic histopathological changes were observed.
Results: spirulina attenuated the severity of the acetic acid -DSS induced colitis through improving the DAI, the colonic oxidative stress markers, TNF-a, IL1B, morphological and partially ameliorate all histopathological changes.
Conclusion: Therapeutically, spirulina could be administered in chronic colitis as potent antioxidant compounds and anti-inflammatory effect of phyocyanin will become a therapeutic strategy of choice for UC to improve the quality of life if sufficient clinical trials are available.
Keywords: spirulina,oxidative stress, tumor necrosis factor .

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