ettesh, R., alnoury, H., ismail, Y., Yacoub, M. (2022). Protective effect of spirulina fusiform in chronic colitis in male albino rats. Benha Medical Journal, 39(Special issue (Academic)), 214-228. doi: 10.21608/bmfj.2022.18446.1111
reham ettesh; heba alnoury; yasmeen ismail; Mary Yacoub. "Protective effect of spirulina fusiform in chronic colitis in male albino rats". Benha Medical Journal, 39, Special issue (Academic), 2022, 214-228. doi: 10.21608/bmfj.2022.18446.1111
ettesh, R., alnoury, H., ismail, Y., Yacoub, M. (2022). 'Protective effect of spirulina fusiform in chronic colitis in male albino rats', Benha Medical Journal, 39(Special issue (Academic)), pp. 214-228. doi: 10.21608/bmfj.2022.18446.1111
ettesh, R., alnoury, H., ismail, Y., Yacoub, M. Protective effect of spirulina fusiform in chronic colitis in male albino rats. Benha Medical Journal, 2022; 39(Special issue (Academic)): 214-228. doi: 10.21608/bmfj.2022.18446.1111
Protective effect of spirulina fusiform in chronic colitis in male albino rats
1pharmacology, faculty of medicine ,kafr-elshekh university, fuwa,egypt
2pharmacology,faculty of medicine ,benha,benha
3Clinical Pharmacology,Faculty of medicine, Benha university,Benha ,Benha .
Abstract
Background/Objectives: In this work, a modified low dose model of induction of ulcerative colitis was used including the administration of single intra-rectal instillation of 1 ml of 5% acetic acid followed by 2% dextran sodium sulfate for 7 days. Moreover, aqueous suspension of Spirulina (500 mg /kg stomach gavage)was prophylactically used 7 days before disease induction . Antioxidant, anti-inflammatory effect was achieved by spirulina . Aim: The aim of this study was to determine the effectiveness of spirulina as a new, safe in treatment of ulcerative colitis Material and methods: Chronic UC was induced by 1ml 5% intracolonic acetic acid instillation in adult male albino rats as single dose following by adding 2% DSS orally in drinking water for 7 days. Intragastric administration of spirulina. (500 mg/kg/day) was administrated 7 days before acetic acid instillation and continued for the end of the experiment. Disease activity index (DAI), colonic oxidative stress markers, tumor necrosis factor (TNF)-a levels, IL1B, and the colonic histopathological changes were observed. Results: spirulina attenuated the severity of the acetic acid -DSS induced colitis through improving the DAI, the colonic oxidative stress markers, TNF-a, IL1B, morphological and partially ameliorate all histopathological changes. Conclusion: Therapeutically, spirulina could be administered in chronic colitis as potent antioxidant compounds and anti-inflammatory effect of phyocyanin will become a therapeutic strategy of choice for UC to improve the quality of life if sufficient clinical trials are available. Keywords: spirulina,oxidative stress, tumor necrosis factor .
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