Darwish, S., Younis, Y., Abo-Amer, Y., Elsharaby, R., Alegaily, H. (2022). Anti-outer-membrane Porin C Antibody as Probable Biomarkers for Ulcerative Colitis (UC). Benha Medical Journal, 39(2), 357-371. doi: 10.21608/bmfj.2022.118947.1537
Samar Darwish; Yehia Younis; Yousry Abo-Amer; Radwa Elsharaby; Hatem Alegaily. "Anti-outer-membrane Porin C Antibody as Probable Biomarkers for Ulcerative Colitis (UC)". Benha Medical Journal, 39, 2, 2022, 357-371. doi: 10.21608/bmfj.2022.118947.1537
Darwish, S., Younis, Y., Abo-Amer, Y., Elsharaby, R., Alegaily, H. (2022). 'Anti-outer-membrane Porin C Antibody as Probable Biomarkers for Ulcerative Colitis (UC)', Benha Medical Journal, 39(2), pp. 357-371. doi: 10.21608/bmfj.2022.118947.1537
Darwish, S., Younis, Y., Abo-Amer, Y., Elsharaby, R., Alegaily, H. Anti-outer-membrane Porin C Antibody as Probable Biomarkers for Ulcerative Colitis (UC). Benha Medical Journal, 2022; 39(2): 357-371. doi: 10.21608/bmfj.2022.118947.1537
Anti-outer-membrane Porin C Antibody as Probable Biomarkers for Ulcerative Colitis (UC)
2Professor of Hepatology, Gastroenterology and Infectious diseases Faculty of medicine – Benha University
3Fellow of Tropical Medicine Mahalla Hepatology Teaching Hospital
4Lecturer of clinical pathology Faculty of medicine –Tanta university
5Assistant professor of Hepatology, Gastroenterology and Infectious diseases Faculty of medicine – Benha University
Abstract
Background: Ulcerative colitis (UC) is the commonest type of inflammatory bowel diseases (IBD) allover the world. Aim of the work: Compare the level of serum anti-outer membrane protein C (anti-Omp C) in UC patients and non-ulcerative colitis patients and correlate its level with the disease activity. Patients and methods: This study included 45 patients with UC and 45 non-ulcerative colitis patients. All cases were submitted to history taking, clinical examination and laboratory analysis (including assessment of anti-ompc antibodies). The cases in the UC group underwent colonic biopsy followed by microscopic histological examination of the obtained samples. Results: Endoscopic Activity Index for UC shows that 71.2% had active UC while 28.8% had inactive UC. The level of anti-ompc antibodies showed a statistically significant increase in the UC-group as compared with the non-UC group (31.11 ± 21.67 and 16.41 ± 15.06 respectively) (p < 0.001). The active UC group had statistically significantly higher level of anti-ompc antibodies as compared with the inactive cases (38.15 ± 18.02 and 26.61± 15.89 respectively) (p=0.005). ROC curve shows that,the best cut off point of anti-ompc level to identify cases with UC from non-ulcerative group was >13.8 with 63.4% sensitivity and 77.6% specificity (p < 0.001). Conclusion: Anti-OMPC may be a useful marker not only for diagnosis of UC but also in determination of the disease activity among UC patients.
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