Anti-outer-membrane Porin C Antibody as Probable Biomarkers for Ulcerative Colitis (UC)

Document Type : Original Article

Authors

1 MBBCH

2 Professor of Hepatology, Gastroenterology and Infectious diseases Faculty of medicine – Benha University

3 Fellow of Tropical Medicine Mahalla Hepatology Teaching Hospital

4 Lecturer of clinical pathology Faculty of medicine –Tanta university

5 Assistant professor of Hepatology, Gastroenterology and Infectious diseases Faculty of medicine – Benha University

Abstract

Background: Ulcerative colitis (UC) is the commonest type of inflammatory bowel diseases (IBD) allover the world.
Aim of the work: Compare the level of serum anti-outer membrane protein C (anti-Omp C) in UC patients and non-ulcerative colitis patients and correlate its level with the disease activity.
Patients and methods: This study included 45 patients with UC and 45 non-ulcerative colitis patients. All cases were submitted to history taking, clinical examination and laboratory analysis (including assessment of anti-ompc antibodies). The cases in the UC group underwent colonic biopsy followed by microscopic histological examination of the obtained samples.
Results: Endoscopic Activity Index for UC shows that 71.2% had active UC while 28.8% had inactive UC. The level of anti-ompc antibodies showed a statistically significant increase in the UC-group as compared with the non-UC group (31.11 ± 21.67 and 16.41 ± 15.06 respectively) (p < 0.001). The active UC group had statistically significantly higher level of anti-ompc antibodies as compared with the inactive cases (38.15 ± 18.02 and 26.61± 15.89 respectively) (p=0.005). ROC curve shows that,the best cut off point of anti-ompc level to identify cases with UC from non-ulcerative group was >13.8 with 63.4% sensitivity and 77.6% specificity (p < 0.001).
Conclusion: Anti-OMPC may be a useful marker not only for diagnosis of UC but also in determination of the disease activity among UC patients.

Keywords

Benha Medical Journal
Volume 39, Issue 2
July and August 2022
Pages 357-371

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