Significance of CXCL9 and Vascular endothelial growth factor-α (VEGF-α) expression in Colorectal adenocarcinoma :(Immunohistochemical Study)

Document Type : Original Article

Authors

1 Pathology department Benha faculty of medicine

2 pathology department benha faculty of medicine

Abstract

Background:Colorectal carcinoma (CRC) is the third most common cancer in the world. The chemokine CXCL9 is a small molecule belongs to (CXC family) which secreted by (IFN-γ) stimulated macrophages. VEGF-α plays central role in the regulation of angiogenesis and lymphangiogenesis.
Aim : This work aimed to evaluate the role of CXCL9 and VEGF α in colorectal adenocarcinoma.

Material and method: This retrospective study was carried upon 50 cases of colorectal adenocarcinoma. CXCL9 and VEGFα immunostaining was done and assessed for each case.

Results: There was an insignificant statistical correlation between both CXCL9 and VEGF -α expression and patient`s age, sex, tumor size and site (P value >0.05). But there was a highly significant inverse statistical correlation between CXCL9 expression and tumor grade, depth of tumor invasion, lymph node metastasis, distant metastasis lymphovascular invasion and tumor stage (P value

Keywords

Benha Medical Journal
Volume 39, Special issue (Academic)
September and October 2022
Pages 183-199

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