Significance of CXCL9 and Vascular endothelial growth factor-α (VEGF-α) expression in Colorectal adenocarcinoma :(Immunohistochemical Study)

Saleh, Samah Ibrahim; Abd El Aziz, Taghreed Abd EL Samea; Omar, Eman Saad; Abd Rabh, Rasha Mahmoud

doi:10.21608/bmfj.2022.18460.1116

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	Significance of CXCL9 and Vascular endothelial growth factor-α (VEGF-α) expression in Colorectal adenocarcinoma :(Immunohistochemical Study)
Article 238, Volume 39, Special issue (Academic), September and October 2022, Page 183-199 PDF (1.23 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.18460.1116
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Authors
Samah Ibrahim Saleh ¹; Taghreed Abd EL Samea Abd El Aziz²; Eman Saad Omar²; Rasha Mahmoud Abd Rabh²
¹Pathology department Benha faculty of medicine
²pathology department benha faculty of medicine
Abstract
Background:Colorectal carcinoma (CRC) is the third most common cancer in the world. The chemokine CXCL9 is a small molecule belongs to (CXC family) which secreted by (IFN-γ) stimulated macrophages. VEGF-α plays central role in the regulation of angiogenesis and lymphangiogenesis. Aim : This work aimed to evaluate the role of CXCL9 and VEGF α in colorectal adenocarcinoma. Material and method: This retrospective study was carried upon 50 cases of colorectal adenocarcinoma. CXCL9 and VEGFα immunostaining was done and assessed for each case. Results: There was an insignificant statistical correlation between both CXCL9 and VEGF -α expression and patient`s age, sex, tumor size and site (P value >0.05). But there was a highly significant inverse statistical correlation between CXCL9 expression and tumor grade, depth of tumor invasion, lymph node metastasis, distant metastasis lymphovascular invasion and tumor stage (P value
Keywords
Keywords; Colorectal adenocarcinoma, CXCL9, VEGF, Angiogenesis


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