Gastric Bacterial Flora in Patients with Helicobacter Pylori Infection with and without Dyspepsia

Document Type : Original Article

Authors

1 Department of Hepatology, Gastroentrology and Infectious Diseases

2 Hepatology, Gastroenterology and Infectious diseases Department, Faculty of Medicine, Benha University, Benha, Egypt.

Abstract

The changes in the gastric environment that occur because of Helicobacter Pylori (H. pylori) infection are complicated and include multiple components. Not only the combination of these factors would influence the components of the gastric microbiota, but also the progression of many disorders. Objective: This study aimed to assay the gastric bacterial microbiota in patients infected with H. pylori with dyspeptic symptoms and without.
Patients and methods: This study involved 70 subjects naive H. pylori infection diagnosed by detection of H. pylori antigen in stool, using H. pylori Ag(OnSite) rapid test .Cases were divided into two equal groups: Group 1: patients with chronic dyspeptic symptoms 3 months ago (symptom started at least 6 months before investigation as regard Rome IV criteria) and Group 2: patients without dyspeptic symptoms with anemia for investigation or for gastro-esophageal varices screening. Upper esophagogastroduodenoscopy done for all participants and Gastric biopsies were taken for bacterial cultures that were assayed by Vitek 2 system to identify colonies of gastric microbiota for all patients.
Results: Isolated gram-negative organisms were higher in non-dyspeptic than dyspeptic group (P = 0.015). Isolated staphylococci were significantly higher in dyspeptic group compared to non-dyspeptic group (P = 0.003), while Streptococci and klebsiella were significantly decreased in dyspeptic group than non-dyspeptic group (P = 0.019 and 0.001 respectively) but other genus were insignificantly different between both groups.
Conclusion: difference of gastric microbiota in patients infected by H. pylori may have role in interaction with it for appearance of gastric disease and dyspepsia

Keywords

Benha Medical Journal
Volume 39, Issue 1
March and April 2022
Pages 319-333

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