Abdel-Monem, S., Soliman, A., Marei, M., Elwia, S., Fawzy, R. (2022). Serum COLL2-1 In Rheumatoid Arthritis: Its Relation to Disease Activity and Severity. Benha Medical Journal, 39(1), 235-246. doi: 10.21608/bmfj.2021.90025.1456
Samia Mohamed Abdel-Monem; Amal Fathy Soliman; Mohammed Moustafa Marei; Sania Khairy Elwia; Rasha Mohamed Fawzy. "Serum COLL2-1 In Rheumatoid Arthritis: Its Relation to Disease Activity and Severity". Benha Medical Journal, 39, 1, 2022, 235-246. doi: 10.21608/bmfj.2021.90025.1456
Abdel-Monem, S., Soliman, A., Marei, M., Elwia, S., Fawzy, R. (2022). 'Serum COLL2-1 In Rheumatoid Arthritis: Its Relation to Disease Activity and Severity', Benha Medical Journal, 39(1), pp. 235-246. doi: 10.21608/bmfj.2021.90025.1456
Abdel-Monem, S., Soliman, A., Marei, M., Elwia, S., Fawzy, R. Serum COLL2-1 In Rheumatoid Arthritis: Its Relation to Disease Activity and Severity. Benha Medical Journal, 2022; 39(1): 235-246. doi: 10.21608/bmfj.2021.90025.1456
Serum COLL2-1 In Rheumatoid Arthritis: Its Relation to Disease Activity and Severity
1Department of Rheumatology @ Rehabilitation- Faculty of Medicine- Benha University
2Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Benha University, Egypt.
3Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Banha University, Egypt.
4Department of Biochemistry, Faculty of Medicine, Banha University, Egypt.
5Rheumatology, Rehabilitation & physical Medicine / Faculty of Medicine / Benha University / Benha / Egypt
Abstract
Abstract: Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by proliferation of immunocompetent cells within synovial membranes. Type II collagen is the main protein component and specific for hyaline cartilage. Aim: This work aimed to measure serum level of Coll2-1, in RA patients ,study its association with disease activity and/or severity, and to determine its ability as a biomarker of the disease status. Patients and methods: This study was conducted on: Forty rheumatoid arthritis patients together with twenty primary knee OA patients and twenty volunteers as control groups. For RA patients; full history was obtained then clinical examination was performed. Disease activity. was assessed by DAS-28 and disease severity by Rheumatoid Arthritis Severity Scale (RASS). X- rays of both hands and feet graded by the Larsen score. Routine laboratory tests and serum Coll2-1 level was measured by ELISA. Results: Statistically significant increase in the mean serum Coll2-1 levels among RA and OA patients compared to the healthy controls (p= 0.001 each). No difference was found between RA and OA (p=0.14). Significant positive correlations (p < 0.05) between serum level of Coll2-1 in RA patients with patients’ ages, morning stiffness duration, tender and swollen joints number , ESR, CRP, DAS-28, radiological grading and RASS. Conclusion: This study highlighted the importance of Coll 2-1 biomarker reflecting disease activity and the destructive processes emerging in the joints of RA patients. It could be a promising tool in the pathogenesis of significant joint activity signaling cartilage and joint destruction. Key words: Coll2-1, Rheumatoid arthritis, Biomarkers.
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