Madkour, S., Youssef, S., Goda, M., Abd Rabh, R. (2022). Significance of (IMP3) In Dysplasia- Adenocarcinoma Sequence in Barrett's Esophagus. (Immunohistochemical Study). Benha Medical Journal, 39(Special issue (Academic)), 125-140. doi: 10.21608/bmfj.2021.18949.1147
Sara Abd El-Fattah Madkour; Samia Ahmed Youssef; Mohebat Helmy Goda; Rasha Mahmoud Abd Rabh. "Significance of (IMP3) In Dysplasia- Adenocarcinoma Sequence in Barrett's Esophagus. (Immunohistochemical Study)". Benha Medical Journal, 39, Special issue (Academic), 2022, 125-140. doi: 10.21608/bmfj.2021.18949.1147
Madkour, S., Youssef, S., Goda, M., Abd Rabh, R. (2022). 'Significance of (IMP3) In Dysplasia- Adenocarcinoma Sequence in Barrett's Esophagus. (Immunohistochemical Study)', Benha Medical Journal, 39(Special issue (Academic)), pp. 125-140. doi: 10.21608/bmfj.2021.18949.1147
Madkour, S., Youssef, S., Goda, M., Abd Rabh, R. Significance of (IMP3) In Dysplasia- Adenocarcinoma Sequence in Barrett's Esophagus. (Immunohistochemical Study). Benha Medical Journal, 2022; 39(Special issue (Academic)): 125-140. doi: 10.21608/bmfj.2021.18949.1147
Significance of (IMP3) In Dysplasia- Adenocarcinoma Sequence in Barrett's Esophagus. (Immunohistochemical Study)
1Pathology department, Faculty of medicine, Benha univesity, Benha, egypt
2Pathology department, Faculty of medicine, Benha university, Egypt
3Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.
4pathology department benha faculty of medicine
Abstract
Background: Barrett's esophagus (BE) is the replacement of the squamous epithelium of the distal esophagus by a metaplastic columnar epithelium. It has been considered the most important precursor lesion for esophageal adenocarcinoma (EAC) through a series of genetic and epigenetic mutations. The oncofetal protein IMP3 is a member of a family of RNA-binding proteins that promotes tumor cell proliferation, adhesion, and invasion. Aim: The aim of this study was to evaluate IMP3 expression in BE and its associated pathological changes through the malignant progression. Materials and Methods: This retrospective study was done upon 51 different esophageal lesions designated as; 20 cases of EAC and 31 cases of BE. IMP3 immunostaining was done and assessed for each case. Results: IMP3 positivity was seen in 3/11 cases (27.5%) of BE-ND, 6/10 cases (60%) of BE-LGD, 9/10 cases (90%) of BE-HGD, and in all (100%) of EAC cases. IMP3 IHC expression was positively correlated with the different grades of BE (BE-ND, BE-LGD, and BE-HGD) and EAC cases (P