ANTENATAL CORTICOSTEROID THERAPY: A COMPARATIVE STUDY OF DEXAMETHASONE AND BETAMETHASONE EFFECTS ON FETAL DOPPLER INDICES

Document Type : Original Article

Authors

1 obstetrics and gynecology,Elmansoura General Hospital

2 Professor of Obstetrics and gynecology Faculty of Medicine-Benha University

3 Lecturer of Obstetrics and gynecology Faculty of Medicine-Benha University

Abstract

Background: Preterm delivery, defined as delivery before 37 weeks of pregnancy, is the leading global reason for neonatal mortality and morbidity. Preterm neonates have serious problems such as respiratory distress syndrome, bronchopulmonary dysplasia, retinopathy, intraventricular hemorrhage and patent ductus arteriosus, one of the most challenging issues of modern perinatology is the prevention of these serious morbidities in infants. Aim of the work The aim of this study is to compare the effects of antenatal administration of corticosteroids in the form of dexamethasone or betamethasone for Enhancement of Fetal Lung Maturity on Doppler Indices (UA, MCA). Patients and Methods: A prospective randomized comparative study was conducted at the Obstetrics and Gynecology Department, Benha University Hospital, Benha – Egypt through the period from October 2018 to June 2019 and was subjected to approval by the Local Ethics Committee of the Department. The study included 84 cases of high risk pregnant women admitted to the department and candidates for corticosteroids therapy for possible preterm birth, Doppler study of the pulsatility index (PI) of the umbilical artery (UA)& the middle cerebral artery (MCA): 24 hrs (day one) and 72 hrs (day three) after the first dose of dexamethasone or betamethasone, Results: the results of study revealed that that there was significant decrease in umbilical artery PI after treatment in both groups from before treatment to afterand there were significant decrease Middle cerebral artery
PIafter. Dexamethasone, Conclusion:
In our study They is no significant difference between dexamethasone and betamethasone used for fetal lung maturity.

Keywords

Benha Medical Journal
Volume 39, Issue 1
March and April 2022
Pages 32-45

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