Abu-Raia, N., Selim, A., Sanad, R., Ibrahim, A., EL noury, H. (2022). Effect of L-arginine and Carvedilol on Peptic Ulcer and Hypertension in Rats. Benha Medical Journal, 39(Special issue (Academic)), 111-124. doi: 10.21608/bmfj.2021.88722.1447
Nashwa Abu-Raia; Ahmed Selim; Rezk Sanad; aya Ibrahim; Heba EL noury. "Effect of L-arginine and Carvedilol on Peptic Ulcer and Hypertension in Rats". Benha Medical Journal, 39, Special issue (Academic), 2022, 111-124. doi: 10.21608/bmfj.2021.88722.1447
Abu-Raia, N., Selim, A., Sanad, R., Ibrahim, A., EL noury, H. (2022). 'Effect of L-arginine and Carvedilol on Peptic Ulcer and Hypertension in Rats', Benha Medical Journal, 39(Special issue (Academic)), pp. 111-124. doi: 10.21608/bmfj.2021.88722.1447
Abu-Raia, N., Selim, A., Sanad, R., Ibrahim, A., EL noury, H. Effect of L-arginine and Carvedilol on Peptic Ulcer and Hypertension in Rats. Benha Medical Journal, 2022; 39(Special issue (Academic)): 111-124. doi: 10.21608/bmfj.2021.88722.1447
Effect of L-arginine and Carvedilol on Peptic Ulcer and Hypertension in Rats
1Lecturer of Clinical Pharmacology, Benha University Faculty of Medicine
2Professor of Clinical Pharmacology, Benha University Faculty of Medicine
3Demonstrator in the Department of Clinical Pharmacology, Faculty of medicine, Kafr El-Sheikh University
4Lecturer of Clinical Pharmacology, Faculty of Medicine, Benha University.
Abstract
Background: Adults with hypertension often suffer from peptic ulcer disease and are more likely to receive drugs for hypertension and peptic ulcer Aim of the study: The aim of this study was to evaluate effect of L-arginine and carvedilol as nitric oxide donors on peptic ulcer and on peptic ulcer hypertension co- morbidity regarding to these parameters: blood pressure, ulcer score, ulcer index, total antioxidant capacity(TAC),nitric oxide(NO), prostaglandinE2(PGE2)and tumor necrosis factor alpha (TNF-α) Methods: Rats were classified into: Group 1: control normal group. Group 2carboxy methylcelluse(CMC) group. Group 3: peptic ulcer (PU)group, Group4: hypertension -PU group, Group 5: PU L-arginine pretreated group, Group6: hypertension-PU L-arginine pretreated group, Group7: PU carvedilol pretreated group, Group8: hypertension -PU carvedilol pretreated group, Group9: hypertension- PU L-arginine treated group, Group 10: hypertension- PU carvedilol treated group Results: Treated groups showed significant improvement in all parameters related to PU and hypertension PU progression and improvement of the histopathology of stomach. Conclusion: Our study revealed that L-arginine and carvedilol showed improvement in blood pressure, ulcer score, ulcer index, TNF-α, TAC, NO and PGE2. there was no significant difference between both drugs. So our drugs have prophylactic effect against PU and hypertension PU co-morbidity and their effect appeared to be mediated, by reductions in oxidative stress and a preservation of gastro protective mechanisms as NO, PG E2 and TAC
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