The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin

Document Type : Original Article

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1 department of pathology ,f aculty of medicine ,Benha univeristy

2 Department of Pathology,Faculty of Medicine, BenhaUniversity, Egypt.

3 lecturer at pathology department, Benha faculty of medicine, Benha

Abstract

Introduction: The histological distinction between squamous cell carcinoma both in-situ and invasive from their benign mimic; irritated seborrheic keratosis is still a difficulty. The aim of this study is to invistigate the diagnostic utility of Insulin-like growth factor II mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 ) in differentiating forementioned cutaneous tumors.
Materials and Methods: This is a retrospective study to include 50 cases , 25(50%) cases of squamous cell carcinoma (SCC), 10 (20%) cases of squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of irradiated seborrheic keratosis (ISK) . The immunohistochemical expression of IMP3and BCL2 was studied .
Results: BCL2 was expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in SCCIS and 4/25 (16%) in invasive SCC cases (p < /p>

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