bassyoni, O., Emara, N., rashad, H. (2022). The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin. Benha Medical Journal, 39(Special issue (Radiology)), 210-219. doi: 10.21608/bmfj.2021.87517.1446
omneya youssef bassyoni; Nashwa Mohamed Emara; heba Mohamed rashad. "The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin". Benha Medical Journal, 39, Special issue (Radiology), 2022, 210-219. doi: 10.21608/bmfj.2021.87517.1446
bassyoni, O., Emara, N., rashad, H. (2022). 'The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin', Benha Medical Journal, 39(Special issue (Radiology)), pp. 210-219. doi: 10.21608/bmfj.2021.87517.1446
bassyoni, O., Emara, N., rashad, H. The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin. Benha Medical Journal, 2022; 39(Special issue (Radiology)): 210-219. doi: 10.21608/bmfj.2021.87517.1446
The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin
1department of pathology ,f aculty of medicine ,Benha univeristy
2Department of Pathology,Faculty of Medicine, BenhaUniversity, Egypt.
3lecturer at pathology department, Benha faculty of medicine, Benha
Abstract
Introduction: The histological distinction between squamous cell carcinoma both in-situ and invasive from their benign mimic; irritated seborrheic keratosis is still a difficulty. The aim of this study is to invistigate the diagnostic utility of Insulin-like growth factor II mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 ) in differentiating forementioned cutaneous tumors. Materials and Methods: This is a retrospective study to include 50 cases , 25(50%) cases of squamous cell carcinoma (SCC), 10 (20%) cases of squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of irradiated seborrheic keratosis (ISK) . The immunohistochemical expression of IMP3and BCL2 was studied . Results: BCL2 was expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in SCCIS and 4/25 (16%) in invasive SCC cases (p < /p>
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