Elsayed, E., Ahmed, H., Abdelaziz, T., Youssef, S. (2022). Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study). Benha Medical Journal, 39(Special issue (Academic)), 63-77. doi: 10.21608/bmfj.2021.46914.1330
Enas Ibrahim Elsayed; Heba Hassan Ahmed; Taghreed Abdelsamee Abdelaziz; Samia Ahmed Youssef. "Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)". Benha Medical Journal, 39, Special issue (Academic), 2022, 63-77. doi: 10.21608/bmfj.2021.46914.1330
Elsayed, E., Ahmed, H., Abdelaziz, T., Youssef, S. (2022). 'Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)', Benha Medical Journal, 39(Special issue (Academic)), pp. 63-77. doi: 10.21608/bmfj.2021.46914.1330
Elsayed, E., Ahmed, H., Abdelaziz, T., Youssef, S. Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study). Benha Medical Journal, 2022; 39(Special issue (Academic)): 63-77. doi: 10.21608/bmfj.2021.46914.1330
Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)
1pathology,faculty of medicine, benha university, benha, Egypt
2pathology, faculty of medicine, benha university,benha, Egypt
3pathology, faculty of medicine, benha university, benha, Egypt
4Pathology Department-Faculty of Medicine-Benha University
Abstract
Background: Lung cancer is the second most common cancer, and the leading cause of cancer mortality. Malignant pleural mesothelioma is a highly aggressive malignant neoplasm, and epithelioid mesothelioma is the commonest histological subtype. MUC4 is a high-molecular weight glycoprotein that encoded by MUC4 gene. Aim: The aim of this study was to evaluate MUC4 expression in LAC, LSqCC, and PEM. Materials and Methods: This retrospective study was done upon 70 different lung and pleural lesions designated as; 30 cases of LAC, 20 cases of LSqCC and 20 cases of PEM. MUC4 immunostaining was done and assessed for each case. Results: There is high significant statistical correlation between MUC4 expression with LAC, LSqCC, and PEM cases (P value=0.0001). 90% and 95% of LAC and LSqCC respectively are positive. All PEM cases are negative. The sensitivity and specificity of MUC4 in differentiating PEM from lung cancer including LAC and LSqCC are 92% and 100% respectively. Significant statistical correlation is found between MUC4 and histological subtype (P value > 0.05), grade (P < 0.01), and TNM stage (P < 0.05) of LAC. Significant statistical inverse correlation is found between MUC4 expression and grade of LSqCC (P value> 0.05). Conclusions: MUC4 IHC can differentiate PEM from LAC and LSqCC. MUC4 expression increases with aggressive LAC, and increases with well-differentiated LSqCC. Keyword: lung cancer, pleural mesothelioma, MUC4. Abbreviations: Lung adenocarcinoma (LAC), Lung squamous cell carcinoma (LSqCC), Pleural epithelioid mesothelioma (PEM).
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