Mohamed Abo El-Khair, M., Gouda, M., Elseaidy, A., Bakr, M., Abdrabh, R. (2022). Prognostic significance of immunohistochemical expression of chemokine receptor (CXCR4) and RAF kinase inhibitor protein (RKIP) in gastric carcinoma and premalignant lesions of the stomach. Benha Medical Journal, 39(Special issue (Academic)), 19-34. doi: 10.21608/bmfj.2021.53467.1359
Mona Ahmed Mohamed Abo El-Khair; Mohebat Helmy Gouda; Adel Zaki Elseaidy; Magda hamed Bakr; Rasha Mahmoud Abdrabh. "Prognostic significance of immunohistochemical expression of chemokine receptor (CXCR4) and RAF kinase inhibitor protein (RKIP) in gastric carcinoma and premalignant lesions of the stomach". Benha Medical Journal, 39, Special issue (Academic), 2022, 19-34. doi: 10.21608/bmfj.2021.53467.1359
Mohamed Abo El-Khair, M., Gouda, M., Elseaidy, A., Bakr, M., Abdrabh, R. (2022). 'Prognostic significance of immunohistochemical expression of chemokine receptor (CXCR4) and RAF kinase inhibitor protein (RKIP) in gastric carcinoma and premalignant lesions of the stomach', Benha Medical Journal, 39(Special issue (Academic)), pp. 19-34. doi: 10.21608/bmfj.2021.53467.1359
Mohamed Abo El-Khair, M., Gouda, M., Elseaidy, A., Bakr, M., Abdrabh, R. Prognostic significance of immunohistochemical expression of chemokine receptor (CXCR4) and RAF kinase inhibitor protein (RKIP) in gastric carcinoma and premalignant lesions of the stomach. Benha Medical Journal, 2022; 39(Special issue (Academic)): 19-34. doi: 10.21608/bmfj.2021.53467.1359
Prognostic significance of immunohistochemical expression of chemokine receptor (CXCR4) and RAF kinase inhibitor protein (RKIP) in gastric carcinoma and premalignant lesions of the stomach
1department of Pathology
Faculty of Medicine - Benha University
Toukh
Egypt
2pathology departement, Benha faculty of medicine- Kafr shoker-Egypt
3Pathology, Benha university, Egypt
Abstract
Background: CXCR4 and RKIP have been implicated in initiation and progression in many cancers, but their role in gastric adenocarcinoma remains vague. Aim: The aim of this work is to assess the possible significance of both markers in gastric adenocarcinoma and premalignant lesions of the stomach. Methods: This retrospective study was carried upon 50 cases of gastric adenocarcinoma and 20 of premalignant lesions. Immunohistochemistry was performed to examine the expression of CXCR4 and RKIP in both gastric adenocarcinoma and premalignant lesions of the stomach. Results: CXCR4 was found to be highly expressed in gastric adenocarcinoma compared to premalignant lesions (P value=0.027). It was significantly correlated with tumor grade (P value=0.027), depth of tumor invasion (P value=0.019), lymph node metastasis (P value=0.025), distant metastasis (P value=0.044) and TNM stage (P value=0.002). No statistically significant correlation between CXCR4 expression and histopathological types (P value=0.8). RKIP expression has no significant correlation with progression from premalignant gastric lesions to adenocarcinoma (P value=0.078). RKIP was negatively associated with advanced tumor grade (P value=0.001), depth of invasion (P value=0.018), distant metastasis (P value=0.029) and TNM stage (P value=0.007). No statistically significant correlation between RKIP expression and histopathological types (P value=0.17) and lymph node status (P value=0.053). No significant correlation between CXCR4 and RKIP expression in studied cases was detected (P value=0.178). Conclusions: These results suggested that CXCR4 might be involved in gastric carcinogenesis. Keyword: Gastric adenocarcinoma, premalignant, CXCR4, RKIP.
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