The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma

Document Type : Original Article

Authors

1 Pathology department, Faculty of medicine, Benha University, Benha, Egypt

2 Pathology department, Faculty of Medicine, Benha University, Benha, Egypt

3 pathology departement, Faculty of medicine, Benha univerisity, Benha, Egypt

4 pathology department, faculty of medicine, benha university, benha

Abstract

Background: Colorectal carcinoma (CRC) is the third most common cancer in the world constituting about 10% of all cancers. ALDH1A1 has been used as a stem cell marker, and plays important functional roles in stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has been demonstrated in multiple types of cancers.
Aim: This work aimed to evaluate ALDH1A1 expression in colorectal adenocarcinoma and determine the relation between ALDH1A1 expression and different clinico-pathological variables.
Material and method: This is a selected retrospective study included 50 different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining was performed for all cases.
Results: There was a highly significant statistical difference between ALDH1A1 expression in studied cases according to tumor site, lymph node metastasis and TNM stage (P value

Keywords

Benha Medical Journal
Volume 39, Special issue (Academic)
September and October 2022
Pages 1-18

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