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Said, E., Abostate, H., Emara, N., Agina, H. (2022). The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma. Benha Medical Journal, 39(Special issue (Academic)), 1-18. doi: 10.21608/bmfj.2021.45812.1326
Eman Mohamed Said; Hanaa Mohamed Abostate; Nashwa Mohamed Emara; Hala Adel Agina. "The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma". Benha Medical Journal, 39, Special issue (Academic), 2022, 1-18. doi: 10.21608/bmfj.2021.45812.1326
Said, E., Abostate, H., Emara, N., Agina, H. (2022). 'The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma', Benha Medical Journal, 39(Special issue (Academic)), pp. 1-18. doi: 10.21608/bmfj.2021.45812.1326
Said, E., Abostate, H., Emara, N., Agina, H. The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma. Benha Medical Journal, 2022; 39(Special issue (Academic)): 1-18. doi: 10.21608/bmfj.2021.45812.1326

The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma

Article 160, Volume 39, Special issue (Academic), September and October 2022, Page 1-18  XML PDF (1.24 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.45812.1326
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Authors
Eman Mohamed Said1; Hanaa Mohamed Abostate email 2; Nashwa Mohamed Emara3; Hala Adel Agina4
1Pathology department, Faculty of medicine, Benha University, Benha, Egypt
2Pathology department, Faculty of Medicine, Benha University, Benha, Egypt
3pathology departement, Faculty of medicine, Benha univerisity, Benha, Egypt
4pathology department, faculty of medicine, benha university, benha
Abstract
Background: Colorectal carcinoma (CRC) is the third most common cancer in the world constituting about 10% of all cancers. ALDH1A1 has been used as a stem cell marker, and plays important functional roles in stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has been demonstrated in multiple types of cancers.
Aim: This work aimed to evaluate ALDH1A1 expression in colorectal adenocarcinoma and determine the relation between ALDH1A1 expression and different clinico-pathological variables.
Material and method: This is a selected retrospective study included 50 different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining was performed for all cases.
Results: There was a highly significant statistical difference between ALDH1A1 expression in studied cases according to tumor site, lymph node metastasis and TNM stage (P value
Keywords
Colorectal adenocarcinoma; ALDH1A1; stem cell marker
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