Mohamed, M., Hassan, S., Khattab, N., Atiaa, S., Abdelmoneim, A. (2021). Correlation between serum ferritin and proteinuria as marker of diabetic nephropathy stage in type 2 diabetic patients. Benha Medical Journal, 38(3), 865-880. doi: 10.21608/bmfj.2021.80833.1428
Mohamed A. Mohamed; Saddam A.A. Hassan; Nabil E. Khattab; Samar Mohamed Atiaa; Abdelmoneim Ahmed Abdelmoneim. "Correlation between serum ferritin and proteinuria as marker of diabetic nephropathy stage in type 2 diabetic patients". Benha Medical Journal, 38, 3, 2021, 865-880. doi: 10.21608/bmfj.2021.80833.1428
Mohamed, M., Hassan, S., Khattab, N., Atiaa, S., Abdelmoneim, A. (2021). 'Correlation between serum ferritin and proteinuria as marker of diabetic nephropathy stage in type 2 diabetic patients', Benha Medical Journal, 38(3), pp. 865-880. doi: 10.21608/bmfj.2021.80833.1428
Mohamed, M., Hassan, S., Khattab, N., Atiaa, S., Abdelmoneim, A. Correlation between serum ferritin and proteinuria as marker of diabetic nephropathy stage in type 2 diabetic patients. Benha Medical Journal, 2021; 38(3): 865-880. doi: 10.21608/bmfj.2021.80833.1428
Correlation between serum ferritin and proteinuria as marker of diabetic nephropathy stage in type 2 diabetic patients
1Internal medicine, faculty of medicine ,Banha university, Benha city, Egypt
2Internal medicine department, faculty of medicine, Benha university, Benha city, Egypt
3Internal medicine, faculty of medicine, Benha university, Benha city ,Egypt
4Internal medicine ,faculty of medicine, Benha university, Benha city,Egypt
5Internal medicine ,Benha faculity of medicine, Benha university, Benha city ,Egypt
Abstract
Background: Increased iron reserves in the body have been linked to the development of type 2 diabetes, as well as diabetic nephropathy, retinopathy and vascular dysfunction. Serum ferritin has been related to the occurrence of CKD. Aim of study: Aiming to look into the link between serum ferritin and proteinuria as a diabetic nephropathy marker in type 2 diabetic patients. subjects and methods: It involved 50 individuals of the same age and gender who were split into two groups: 25 type 2 diabetic patients with proteinuria and 25 apparently healthy volunteers (hospital personnel) with no history of diabetes who served as the control group. The Enzyme-linked immunosorbent assay (ELIZA) kit for quantitative detection of human serum ferritin was used to estimate serum ferritin. Results: In the current study, serum ferritin levels in diabetics with proteinuria showed a high significant rise when compared to the control group. (p < 0.001). The comparative present study, the mean ± SD of diabetic patients with nephropathy, serum ferritin was 513.91±260.06 than that of control 133.42±186.66. The current study found a high significant positive relationship between ferritin and 24h protein in diabetic patients with nephropathy(r=0.512, p=0.009), show no significant positive association in control group (r=0.02, p=0.94). Conclusion: serum ferritin can be considered as an independent predicting marker of diabetic nephropathy as well as an excellent diagnostic marker for patients with clinical diabetic nephropathy.
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