Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.

Document Type : Original Article

Authors

1 department of physiology, faculty of medicine Benha university

2 department of physiology faculty of medecine Benha university

3 Department of physiology,Faculty of medicine,Benha university.

4 department of physiology faculty of medicine Benha university

5 Physiology Department-Faculty of Medicine-Benha University

Abstract

Background: Menopause is a biological process that can cause various troublesome symptoms such as hot flashes and emotional changes but can also affect cognitive functions. Soy isoflavones (SIF), are natural compounds that gained popularity as an alternative treatment for menopausal symptoms. Aim: The aim of this work was to investigate the effect of isoflavone treatment on memory in ovariectomized female albino rats. Method: 32 female albino rats were divided into 4 groups consisting of 8 rats in each group; sham, Sham+isoflavone, bilateral Ovariectomy (OVX), OVX + isoflavone. After isoflavone treatment , the animals underwent the novel object recognition test (NORT), and their performance was evaluated. at the end of the experiment. Gaba amino butyric acid (GABA) and glutamate were measured in hippocampal tissues and hormonal level of follicle stimulating hormone (FSH) & 17β-estradiol (E2) were measured in serum.
Results: Animals with ovariectomy showed significant increase (P

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