The Relation between Serum Progranulin and Platelet Count in Immune Thrombocytopenia Patients.

Document Type : Original Article

Authors

1 medical university

2 clinical & chemical pathology dep., Faculty of Medicine, Benha university , Egypt

3 clinical & chemical pathology department,faculty of medicine , Benha university , Egypt.

4 clinical & chemical pathology department,faculty of medicine, Benha university, Egypt.

Abstract

Background: Immune thrombocytopenia (ITP) is an autoimmune disease with excessive platelet destruction and reduced platelet production. Progranulin (PGRN) has a protective effect against autoimmune diseases by competitive binding tumor necrosis factor-α receptors. Thus, we assessed the serum progranulin level in relation to platelet count in ITP patients, pre-and post-induction of corticosteroid therapy.
Methods: A case – control study was conducted on 30 ITP patients and 30 apparently healthy subjects serving as acontrol group. Platelet count and serum progranulin levels were measured in newly diagnosed ITP patients before and 3−7 days after starting corticosteroid treatment.
Results: The mean serum level of PGRN was significantly higher in ITP patients pre-treatment compared to healthy control subjects (P

Keywords

Benha Medical Journal
Volume 38, Issue 1
April 2021
Pages 334-343

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