Abd Allah, M., Abo Elgheit Dawood, N., Amer, R., Abd Elsamea, T., Elbalshy, A. (2021). Role of Prostatic Stem Cell Antigen (PSCA) and Snail in Different Prostatic Lesions) (An immunohistochemical study. Benha Medical Journal, 38(Academic issue), 166-185. doi: 10.21608/bmfj.2021.146411
Marwa Abd Allah; Nancy Abo Elgheit Dawood; Ranih Amer; Taghreed Abd Elsamea; Abd Ellatif Elbalshy. "Role of Prostatic Stem Cell Antigen (PSCA) and Snail in Different Prostatic Lesions) (An immunohistochemical study". Benha Medical Journal, 38, Academic issue, 2021, 166-185. doi: 10.21608/bmfj.2021.146411
Abd Allah, M., Abo Elgheit Dawood, N., Amer, R., Abd Elsamea, T., Elbalshy, A. (2021). 'Role of Prostatic Stem Cell Antigen (PSCA) and Snail in Different Prostatic Lesions) (An immunohistochemical study', Benha Medical Journal, 38(Academic issue), pp. 166-185. doi: 10.21608/bmfj.2021.146411
Abd Allah, M., Abo Elgheit Dawood, N., Amer, R., Abd Elsamea, T., Elbalshy, A. Role of Prostatic Stem Cell Antigen (PSCA) and Snail in Different Prostatic Lesions) (An immunohistochemical study. Benha Medical Journal, 2021; 38(Academic issue): 166-185. doi: 10.21608/bmfj.2021.146411
Role of Prostatic Stem Cell Antigen (PSCA) and Snail in Different Prostatic Lesions) (An immunohistochemical study
Department of pathology, Benha faculty of medicine, Benha University, Egypt.
Abstract
Background: Prostatic carcinoma (PCa) represents the second most common cancer, and the fifth leading cause of cancer death among males worldwide. PSCA is a GPI-anchored cell surface protein. It belongs to the Thy-1/Ly-6 family which shows a functional diversity ranging from T-cell activation to apoptosis regulation. Snail is one of zinc finger proteins which are transcriptional repressors of E-cadherin. Aim: To study PSCA and Snail expression in different prostatic lesions to evaluate their roles in PCa. Material and Methods: This retrospective study was done upon 80 different prostatic lesions; 17 cases of BPH, 13 cases of HGPIN, and 50 cases of PCa. PSCA and Snail immunostaining was done and assessed for each case. Results: There was a highly significant statistical correlation between both PSCA and Snail expressions and histopathological type (P-value<0.01). PSCA expression showed a highly significant statistical correlation with Gleason score, tumor grade and stage (P-value<0.01), and a significant correlation with PSA, and peri-neural invasion (P-value<0.05). Snail expression showed a highly significant statistical correlation with Gleason score and tumor grade (P-value<0.01), and a significant correlation with lymph node metastasis and tumor stage (P-value<0.05). There was a highly significant statistical correlation between PSCA and Snail immune-expression (P-value<0.01). Conclusion: PSCA and Snail expressions correlate with the most important prognostic clinicopathological variables in PCa, thus they may represent a useful predictor of prognosis.