El-Gendy, E., Zakaria, R., Abd Elsamee, T., Agina, H., El badawy, R. (2021). Significance of Toll-like Receptor 4 ( TLR4 )& Liver Fatty Acid-binding Protein (L-FABP) Expression in Hepatocellular Carcinoma An Immunohistochemical Study. Benha Medical Journal, 38(Academic issue), 92-111. doi: 10.21608/bmfj.2020.130879
Eman El-Gendy; Ranih Zakaria; Taghreed Abd Elsamee; Hala Agina; Reda El badawy. "Significance of Toll-like Receptor 4 ( TLR4 )& Liver Fatty Acid-binding Protein (L-FABP) Expression in Hepatocellular Carcinoma An Immunohistochemical Study". Benha Medical Journal, 38, Academic issue, 2021, 92-111. doi: 10.21608/bmfj.2020.130879
El-Gendy, E., Zakaria, R., Abd Elsamee, T., Agina, H., El badawy, R. (2021). 'Significance of Toll-like Receptor 4 ( TLR4 )& Liver Fatty Acid-binding Protein (L-FABP) Expression in Hepatocellular Carcinoma An Immunohistochemical Study', Benha Medical Journal, 38(Academic issue), pp. 92-111. doi: 10.21608/bmfj.2020.130879
El-Gendy, E., Zakaria, R., Abd Elsamee, T., Agina, H., El badawy, R. Significance of Toll-like Receptor 4 ( TLR4 )& Liver Fatty Acid-binding Protein (L-FABP) Expression in Hepatocellular Carcinoma An Immunohistochemical Study. Benha Medical Journal, 2021; 38(Academic issue): 92-111. doi: 10.21608/bmfj.2020.130879
Significance of Toll-like Receptor 4 ( TLR4 )& Liver Fatty Acid-binding Protein (L-FABP) Expression in Hepatocellular Carcinoma An Immunohistochemical Study
1Department of Pathology, Benha faculty of medicine, Benha University, Egypt
2Department of Hepatology, Gastroentrology and Infectious Diseases, Benha faculty of medicine, Benha University, Egypt
Abstract
Back ground: Persistent inflammatory conditions can induce tumorigenesis . It is therefore very important to explore the molecular mechanisms involved in progression from chronic hepatitis to cirrhosis to HCC - to identify factors useful for the development of effective therapies that improve patient survival. Aim of the study: Evaluation of TLR-4 and L-FABP expression in cases of chronic hepatitis, cirrhosis and HCC and correlate them with clinicopathological parameters. Methods: A retrospective, immunohistochemical study was performed on 50 liver cases; 32 cases of HCC, 10 cases of chronic hepatitis C, and 8 cases of cirrhosis. Results: There was statistical significant increase in TLR-4 expression in HCC than both chronic liver hepatitis and cirrhosis (P<0.05). There was positive statistical significant correlation between TLR-4expression and size & grade of HCC (P<0.05) . There was highly statistical significant decrease in L-FABP expression in HCC than both chronic liver hepatitis and cirrhosis (P< 0.001). Conclusion: TLR-4 has a role in hepatocarcinogenesis as TLR-4 expression increased with progression from chronic hepatitis to cirrhosis to HCC. Increased TLR-4 expression associated with large tumor size and higher grade of HCC, so it may serve a tool for prognosis of HCC. L-FABP expression decreased with progression from chronic hepatitis to cirrhosis to HCC. So its downregulation may contribute in pathogenesis of HCC.